98-58-8Relevant articles and documents
NOVEL COMPOUND, PREPARATION METHOD THEREOF, AND USE THEREOF
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Paragraph 530-534, (2021/07/24)
The present invention relates to a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing the same as an active ingredient. The method for preparing a biomaterial to which a compound represented by formula 2 is coupled, of the present invention, allows the compound represented by formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.
Method for rapidly preparing N-benzenesulfonyl amino acid ester compound
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Paragraph 0017, (2021/05/12)
The invention discloses a method for rapidly preparing an N-benzenesulfonyl amino acid ester compound. The invention mainly relates to chemical synthesis. A two-step one-pot strategy is adopted, substituted phenylmercaptan is used as a raw material, in-situ generated benzenesulfonyl chloride acts with hydrochloride of amino acid ester to obtain the N-benzenesulfonyl amino acid ester compound, the strategy is mild in condition, high in yield and high in reaction efficiency, and can be used for rapidly preparing the formula (I) compound and derivatives or analogues thereof. The method for rapidly preparing the N-benzenesulfonyl amino acid ester compound is simple to operate, mild in condition, high in yield and efficiency and relatively high in application value.
Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao
, (2021/09/20)
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.