4-(Bromomethyl)phenylaceticacidphenacylester

Base Information

• Chemical Name: 4-(Bromomethyl)phenylaceticacidphenacylester
• CAS No.: 7398-42-7
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 2916399090
• Mol file: 7398-42-7.mol

Synonyms:methyl 2-[4-(bromomethyl)phenyl]acetate;

Chemical Property of 4-(Bromomethyl)phenylaceticacidphenacylester

Chemical Property:

• Boiling Point: 290.597oC at 760 mmHg
• Flash Point: 129.549oC
• PSA: 26.30000
• Density: 1.416g/cm3
• LogP: 2.29700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-(Bromomethyl)phenylacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Bromomethyl)phenylaceticacidphenacylester

There total 8 articles about 4-(Bromomethyl)phenylaceticacidphenacylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-bromophenylacetic acid (13737-36-5) → methyl 2-(4-(bromomethyl)phenyl)acetate (7398-42-7)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 2h;

Reference yield: 100.0%

4-bromophenylacetic acid (13737-36-5) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 2-(4-(bromomethyl)phenyl)acetate (7398-42-7)

Guidance literature:

In methanol; hexane; benzene; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/anie.201205201

Reference yield: 94.3%

chloro-trimethyl-silane (75-77-4) + 4-bromophenylacetic acid (13737-36-5) → methyl 2-(4-(bromomethyl)phenyl)acetate (7398-42-7)

Guidance literature:

In methanol; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

methyl p-tolylacetate

4-bromophenylacetic acid

diazomethyl-trimethyl-silane

methanol

Downstream raw materials:

3'',3'''-dichloro-5'',5'''-di(methoxycarbonyl)-4'',4'''-di[p-[(methoxycarbonyl)methyl]benzyloxy]-4',4'-diphenyl-3β-(3'-buten-1'-yl)cholestane

(4-cyanomethyl-phenyl)-acetic acid methyl ester

methyl 4-(hydroxymethyl)phenylacetate

methyl 2-[4-(pyrrolidin-1-ylmethyl)phenyl]acetate

Refernces

• 1、 -. "OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS". Paragraph 0307-0310. . Retrieved 2018/06/12.
• 2、 Schmidt, Jurema,Rotter, Marco,Weiser, Tim,Wittmann, Sandra,Weizel, Lilia,Kaiser, Astrid,Heering, Jan,Goebel, Tamara,Angioni, Carlo,Wurglics, Mario,Paulke, Alexander,Geisslinger, Gerd,Kahnt, Astrid,Steinhilber, Dieter,Proschak, Ewgenij,Merk, Daniel. "A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase to Counter Nonalcoholic Steatohepatitis". supporting information. p. 7703 - 7724. Retrieved 2017/10/06.