TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE

Base Information

• Chemical Name: TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE
• CAS No.: 75178-87-9
• Molecular Formula: C9H19NO3
• Molecular Weight: 189.255
• Hs Code.: 2924199090
• Mol file: 75178-87-9.mol

Synonyms:TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE;

Chemical Property of TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE

Chemical Property:

• Vapor Pressure: 9.39E-05mmHg at 25°C
• Melting Point: 29 °C
• Refractive Index: n20/D 1.456
• Boiling Point: 302.7oC at 760 mmHg
• PKA: 12.80±0.46(Predicted)
• Flash Point: 29oC
• PSA: 58.56000
• Density: 1.02 g/mL at 20oC(lit.)
• LogP: 1.67450
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(t-Boc-amino)-1-butanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Building block for spermidine analogues 4-(tert-ButoxycarbonylaMino)-1-butanol can be used as an intermediate for the synthesis of polymers used for in vivo delivery polyconjugate systems.

Technology Process of TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE

There total 15 articles about TERT-BUTYL N-(4-HYDROXYBUTYL)CARBAMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Aminobutanol (13325-10-5) + di-tert-butyl dicarbonate (24424-99-5) → (4-hydroxybutyl)carbamic acid tert-butyl ester (75178-87-9)

Guidance literature:

With triethylamine; In dichloromethane; for 10h; Inert atmosphere;

DOI:10.1021/ol900481e

Reference yield: 100.0%

5-hydroxypentylamine (2508-29-4) + di-tert-butyl dicarbonate (24424-99-5) → (4-hydroxybutyl)carbamic acid tert-butyl ester (75178-87-9)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 2.5h;

DOI:10.3762/bjoc.10.35

Reference yield: 99.0%

tert-butyl 2-oxopyrrolidine-1-carboxylate (85909-08-6) → (4-hydroxybutyl)carbamic acid tert-butyl ester (75178-87-9)

Guidance literature:

With Cp*RuCl{(C6H5)2P-(CH2)2NH2-κ2-P,N}; potassium tert-butylate; hydrogen; In tert-butyl alcohol; at 80 ℃; for 36h; under 22502.3 Torr; Autoclave;

DOI:10.1002/anie.200805307

upstream raw materials:

4-Aminobutanol

di-tert-butyl dicarbonate

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

ethyl (2E)-4-[(tert-butoxycarbonyl)amino]but-2-enoate

Downstream raw materials:

2-(4-tert-butoxycarbonylaminobutoxy)-6-hydroxybenzoic acid methyl ester

toluene-4-sulfonic acid 4-tert-butoxycarbonylaminobutyl ester

tert-butyl (4-((tert-butyldiphenylsilyl)oxy)butyl)carbamate

N-[(tert-butoxy)carbonyl]-4-chloro-butylamine

Refernces

• 1、 Song, Suhee,Lee, Joonhee,Kweon, Songa,Song, Jaeeun,Kim, Kyuseok,Kim, Byeong-Su. "Hyperbranched Copolymers Based on Glycidol and Amino Glycidyl Ether: Highly Biocompatible Polyamines Sheathed in Polyglycerols". . p. 3632 - 3639. Retrieved 2016.
• 2、 Connon, Stephen J.,Ghanim, Magda,Kelly, Vincent P.,McDonnell, Ciara M.,Mike Southern, J.. "De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P". supporting information. . Retrieved 2022/01/24.
• 3、 Bazan, Bart?omiej,Pa?asz, Aleksandra,Skalniak, ?ukasz,Cie?, Dariusz,Buda, Szymon,J?drzejowska, Katarzyna,G?omb, Sonia,Kamzol, Daniel,Czarnota, Kinga,Latos, Krystian,Kozie?, Krzysztof,Musielak, Bogdan. "Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells". supporting information. p. 6045 - 6058. Retrieved 2021/07/25.