tert-Butyl 4-chlorobutylcarbamate

Base Information

• Chemical Name: tert-Butyl 4-chlorobutylcarbamate
• CAS No.: 95388-79-7
• Molecular Formula: C9H18ClNO2
• Molecular Weight: 207.7
• Hs Code.: 2924199090
• Mol file: 95388-79-7.mol

Synonyms:N-(tert-Butoxycarbonyl)-4-chlorobutylamine;tert-Butyl (4-chlorobutyl)carbamate;Carbamic acid, N-(4-chlorobutyl)-, 1,1-dimethylethyl ester;Carbamic acid, (4-chlorobutyl)-, 1,1-dimethylethyl ester (9Cl);

Chemical Property of tert-Butyl 4-chlorobutylcarbamate

Chemical Property:

• Vapor Pressure: 0.00178mmHg at 25°C
• Refractive Index: 1.449
• Boiling Point: 292.9 °C at 760 mmHg
• PKA: 12.78±0.46(Predicted)
• Flash Point: 130.9 °C
• PSA: 38.33000
• Density: 1.034 g/cm³
• LogP: 2.92100
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-Chlorobutylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 4-chlorobutylcarbamate

There total 6 articles about tert-Butyl 4-chlorobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (95388-79-7)

Guidance literature:

Reference yield: 82.0%

methanesulfonic acid 4-tert-butoxycarbonylaminobutyl ester (174626-25-6) → N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (95388-79-7)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 25 ℃; for 72h;

DOI:10.1002/anie.201812925

Reference yield: 12.0%

t-butyl piperidinecarboxylate (75844-69-8) → N-[(tert-butoxy)carbonyl]-4-chloro-butylamine (95388-79-7) + tert-butyl (4-chlorobutyl)(formyl)carbamate

Guidance literature:

With ammonium peroxydisulfate; N-chloro-succinimide; silver nitrate; In water; acetone; at 22 - 23 ℃; for 0.5h; Inert atmosphere;

upstream raw materials:

N-tert-butoxycarbonyl-3-aminopropanol

(4-hydroxybutyl)carbamic acid tert-butyl ester

N-(tert-butyloxycarbonyl)-5-aminopentanol

di-tert-butyl dicarbonate

Refernces

• 1、 Boddy, Alexander J.,Affron, Dominic P.,Cordier, Christopher J.,Rivers, Emma L.,Spivey, Alan C.,Bull, James A.. "Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle “Stitching” by N–H Insertion and Cyclization". . p. 1458 - 1462. Retrieved 2019/01/04.
• 2、 -. "CHEMICAL COMPOUNDS". Page/Page column 78. . Retrieved 2010/10/20.