Ethanone, 1-(4-ethoxy-3-methoxyphenyl)-

Base Information

• Chemical Name: Ethanone, 1-(4-ethoxy-3-methoxyphenyl)-
• CAS No.: 75665-89-3
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• DSSTox Substance ID: DTXSID10442396
• Nikkaji Number: J743.514B
• Wikidata: Q82259649
• Mol file: 75665-89-3.mol

Synonyms:Ethanone, 1-(4-ethoxy-3-methoxyphenyl)-;1-(4-Ethoxy-3-methoxyphenyl)ethanone;75665-89-3;SCHEMBL10764055;DTXSID10442396;3'-Methoxy-4'-ethoxyacetophenone;4'-ethoxy-3'-methoxyacetophenone;AKOS000167962;1-(4-ethoxy-3-methoxyphenyl)ethan-1-one;EN300-1855814;A1-05664

Chemical Property of Ethanone, 1-(4-ethoxy-3-methoxyphenyl)-

Chemical Property:

• PSA: 35.53000
• LogP: 2.29650
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Ethoxy-3-methoxyphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)C(=O)C)OC

Technology Process of Ethanone, 1-(4-ethoxy-3-methoxyphenyl)-

There total 22 articles about Ethanone, 1-(4-ethoxy-3-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl iodide (75-03-6) + 1-(3-methoxy-4-hydroxyphenyl)ethanone (498-02-2) → 1-<(4-ethoxy-3-methoxy)phenyl>ethan-1-one (75665-89-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1016/S0040-4020(97)00460-2

Reference yield:

1-(4'-ethoxy-3'-methoxyphenyl)ethanol → 1-<(4-ethoxy-3-methoxy)phenyl>ethan-1-one (75665-89-3)

Guidance literature:

With 2,6-dimethylpyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; lithium perchlorate; In water; acetonitrile; Reagent/catalyst; Electrolysis;

DOI:10.1016/j.electacta.2013.05.112

Reference yield:

1-(4-ethoxy-3-methoxyphenyl)-2-(2-methoxyphenoxy)ethanone (186255-41-4) → 1-<(4-ethoxy-3-methoxy)phenyl>ethan-1-one (75665-89-3) + 2-methoxy-phenol (90-05-1)

Guidance literature:

With RuH₂(CO)(PPh₃)3; hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In ⁽²⁾H₈-toluene; at 135 ℃; for 20h; under 760.051 Torr;

DOI:10.1039/c2dt31065a

upstream raw materials:

Ethyl p-ethoxy-m-methoxybenzoylacetate

2-ethoxyanisole

acetyl chloride

4-acetoxy-3-methoxycarbonyl-4-(3-methoxy-4-ethoxyphenyl)but-3-ene-2-one

Downstream raw materials:

2,5-bis-(4-ethoxy-3-methoxy-phenyl)-furan-3-carboxylic acid ethyl ester

2,5-bis-(4-ethoxy-3-methoxy-phenyl)-furan-3-carboxylic acid

1,4-bis-(4-ethoxy-3-methoxy-phenyl)-butane-1,4-dione

2,5-bis-(4-ethoxy-3-methoxy-phenyl)-furan

Refernces

• 1、 Shiraishi, Takumi,Sannami, Yumi,Kamitakahara, Hiroshi,Takano, Toshiyuki. "Comparison of a series of laccase mediators in the electro-oxidation reactions of non-phenolic lignin model compounds". . p. 440 - 446. Retrieved 2013/10/01.
• 2、 Smith, Keith,El-Hiti, Gamal A.,Jayne, Anthony J.,Butters, Michael. "Acetylation of aromatic ethers using acetic anhydride over solid acid catalysts in a solvent-free system. Scope of the reaction for substituted ethers". . p. 1560 - 1564. Retrieved 2007/10/03.