4-amino-2-chloro-3-fluorobenzaldehyde

Base Information

• Chemical Name: 4-amino-2-chloro-3-fluorobenzaldehyde
• CAS No.: 757247-98-6
• Molecular Formula: C7H5ClFNO
• Molecular Weight: 173.574
• Hs Code.: 2921420090
• Mol file: 757247-98-6.mol

Synonyms:4-Amino-2-chloro-3-fluorobenzaldehyde;

Chemical Property of 4-amino-2-chloro-3-fluorobenzaldehyde

Chemical Property:

• Boiling Point: 298.4±40.0 °C(Predicted)
• PKA: -0.58±0.10(Predicted)
• PSA: 43.09000
• Density: 1.451±0.06 g/cm3(Predicted)
• LogP: 2.45500

Purity/Quality:

95% ^*data from raw suppliers

4-Amino-2-chloro-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-2-chloro-3-fluorobenzaldehyde

There total 2 articles about 4-amino-2-chloro-3-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2-fluoroaniline (2106-04-9) → 4-amino-2-chloro-3-fluoro-benzaldehyde (757247-98-6)

Guidance literature:

3-chloro-2-fluoroaniline; With hydrogenchloride; copper dichloride; In water; dimethyl sulfoxide; at 0 - 90 ℃; for 13h;

With sodium hydroxide; In water; dimethyl sulfoxide; pH=8;

Reference yield:

3-chloro-2-fluoroaniline (2106-04-9) + copper(II) chloride (7447-39-4) → 4-amino-2-chloro-3-fluoro-benzaldehyde (757247-98-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In dimethyl sulfoxide;

Reference yield:

4-amino-2-chloro-3-fluoro-benzaldehyde (757247-98-6) → 4-amino-2-chloro-3-fluorobenzonitrile (757247-99-7)

Guidance literature:

4-amino-2-chloro-3-fluoro-benzaldehyde; With hydroxylamine hydrochloride; In pyridine; water; at 20 ℃; for 1h;

With copper(II) sulfate; triethylamine; In pyridine; dichloromethane; water;

With formic acid; dicyclohexyl-carbodiimide; more than 3 stages;

upstream raw materials:

3-chloro-2-fluoroaniline

copper(II) chloride

Downstream raw materials:

4-amino-2-chloro-3-fluorobenzonitrile

Refernces

• 1、 -. "BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION". . . Retrieved 2008/06/13.