Acetamide, N-(4-aminophenyl)-, monohydrochloride

Base Information

• Chemical Name: Acetamide, N-(4-aminophenyl)-, monohydrochloride
• CAS No.: 43036-07-3
• Molecular Formula: C8H10 N2 O . Cl H
• Molecular Weight: 186.641
• Hs Code.: 2924299090
• European Community (EC) Number: 256-052-1
• DSSTox Substance ID: DTXSID5068445
• Mol file: 43036-07-3.mol

Synonyms:43036-07-3;Acetamide, N-(4-aminophenyl)-, monohydrochloride;4-Acetamidoanilinium chloride;4'-Aminoacetanilide hydrochloride;N-(4-aminophenyl)acetamide;hydrochloride;EINECS 256-052-1;4-AMINOACETANILIDE HYDROCHLORIDE;Acetamide,N-(4-aminophenyl)-,hydrochloride(1:1);Acetamide, N-(4-aminophenyl)-, hydrochloride (1:1);P-aminoacetanilide hydrochloride;SCHEMBL4819296;4-Acetamidoaniline hydrochloride;DTXSID5068445;MFCD00050695;4'-aminoacetanilide hydrochloride salt;AKOS024318888;4'-Aminoacetanilide hydrochloride, 98%;N-Acetyl-1,4-phenylenediamine hydrochloride;FT-0617375

Chemical Property of Acetamide, N-(4-aminophenyl)-, monohydrochloride

Chemical Property:

• Vapor Pressure: 0.00802mmHg at 25°C
• Melting Point: 165 °C
• Boiling Point: 267.7°C at 760 mmHg
• Flash Point: 115.7°C
• PSA: 55.12000
• LogP: 2.68340
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.0559907
• Heavy Atom Count: 12
• Complexity: 139

Purity/Quality:

98%Min ^*data from raw suppliers

N1-(4-Aminophenyl)acetamide hydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)N.Cl

Technology Process of Acetamide, N-(4-aminophenyl)-, monohydrochloride

There total 5 articles about Acetamide, N-(4-aminophenyl)-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C24H18N2O3 → 2,3-diphenylmaleic anhydride (4808-48-4) + acetic acid-(4-amino-anilide); hydrochloride (43036-07-3)

Guidance literature:

C₂₄H₁₈N₂O₃; With potassium hydroxide; In ethanol; water; at 80 ℃; for 2h; Green chemistry;

With hydrogenchloride; In ethanol; water; pH=4; Green chemistry;

DOI:10.1039/c6gc01318j

Reference yield: 86.0%

1,4-phenylenediamine (106-50-3) → acetic acid-(4-amino-anilide); hydrochloride (43036-07-3)

Guidance literature:

With hydrogenchloride; acetic anhydride; In water;

Reference yield:

C14H21BN2O3 → acetic acid-(4-amino-anilide); hydrochloride (43036-07-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/adsc.202101043

upstream raw materials:

N-acetyl-p-phenylenediamine

1,4-phenylenediamine

Downstream raw materials:

Ethylcyanylglyoxylat-4-acetamidophenylhydrazon

C₂₄H₂₃N₅O₄

Diethylmesoxalat-4-acetamidophenylhydrazon

Mesoxalsaeure-4-acetamidophenylhydrazon

Refernces

• 1、 Guan, Qi,Jiang, Mingyang,Wu, Junhui,Zhai, Yanpeng,Wu, Yue,Bao, Kai,Zhang, Weige. "Direct cycle between co-product and reactant: An approach to improve the atom economy and its application in the synthesis and protection of primary amines". . p. 5794 - 5799. Retrieved 2016/11/06.
• 2、 -. "Process for the monoacylation of an aromatic primary diamine". . . Retrieved 2008/06/13.