4-cyclopropylbenzenecarboxylic acid chloride

Base Information

• Chemical Name: 4-cyclopropylbenzenecarboxylic acid chloride
• CAS No.: 76274-94-7
• Molecular Formula: C10H9ClO
• Molecular Weight: 180.634
• Mol file: 76274-94-7.mol

Synonyms:

Chemical Property of 4-cyclopropylbenzenecarboxylic acid chloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

4-CyclopropylbenzoylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-cyclopropylbenzenecarboxylic acid chloride

There total 1 articles about 4-cyclopropylbenzenecarboxylic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-cyclopropylbenzoic acid (1798-82-9) → 4-cyclopropylbenzenecarboxylic acid chloride (76274-94-7)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 80 ℃; for 5h;

DOI:10.1021/jm900179y

Reference yield: 36.0%

[2-fluoro-4-[2-(3-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]phenyl]methanamine + 4-cyclopropylbenzenecarboxylic acid chloride (76274-94-7) → 4-cyclopropyl-N-([2-fluoro-4-[2-(3-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-7-yl]phenyl]methyl)benzamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -10 ℃; for 0.5h; Inert atmosphere;

Reference yield: 35.0%

methyl 6-(methylthio)-1,2-dihydro-3H-pyrrolo<1,2-a>pyrrole-1-carboxylate (89541-90-2) + 4-cyclopropylbenzenecarboxylic acid chloride (76274-94-7) → methyl 5-(4-cyclopropylbenzoyl)-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate (89542-04-1)

Guidance literature:

In toluene; for 36h; Heating;

DOI:10.1021/jm00126a010

upstream raw materials:

4-cyclopropylbenzoic acid

Downstream raw materials:

4-cyclopropyl-benzoic acid ethyl ester

N,N-dimethyl-4-cyclopropylbenzamide

methyl 5-(4-cyclopropylbenzoyl)-6-methylthio-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylate

[5-(4-Cyclopropyl-benzoyl)-1-methyl-4-methylsulfanyl-1H-pyrrol-2-yl]-acetic acid ethyl ester

Refernces

• 1、 Szabó, Gyorgy,Varga, Balázs,Páyer-Lengyel, Dóra,Szemzo, Attila,Erdélyi, Péter,Vukics, Krisztina,Szikra, Judit,Hegyi, éva,Vastag, Mónika,Kiss, Béla,Laszy, Judit,Gyertyán, István,Fischer, János. "Chemical and biological investigation of cyclopropyl containing diaryl-pyrazole-3-carboxamides as novel and potent cannabinoid type 1 receptor antagonists". experimental part. p. 4329 - 4337. Retrieved 2010/02/28.
• 2、 Muchowski, Joseph M.,Galeazzi, Edvige,Greenhouse, Robert,Guzman, Angel,Perez, Virginia,et al.. "Synthesis and Antiinflammatory and Analgesic Activity of 5-Aroyl-6-(methylthio)-1,2-dihydro-3H-pyrrolopyrrole-1-carboxylic Acids and 1-Methyl-4-(methylthio)-5-aroylpyrrole-2-acetic Acids". . p. 1202 - 1207. Retrieved 2007/10/02.