4-cyclopyl-benzoic-acid ethyl ester

Base Information

• Chemical Name: 4-cyclopyl-benzoic-acid ethyl ester
• CAS No.: 35391-85-6
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 35391-85-6.mol

Synonyms:4-cyclopyl-benzoic-acid ethyl ester;ethyl 4-cyclopropylbenzoate;Benzoic acid, 4-cyclopropyl-, ethyl ester

Chemical Property of 4-cyclopyl-benzoic-acid ethyl ester

Chemical Property:

• Boiling Point: 132 °C(Press: 7 Torr)
• PSA: 26.30000
• Density: 1.060 g/cm3
• LogP: 2.74070

Purity/Quality:

97% ^*data from raw suppliers

4-CYCLOPROPYL-BENZOIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-cyclopyl-benzoic-acid ethyl ester

There total 10 articles about 4-cyclopyl-benzoic-acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

tricyclopropylbismuthane (925430-09-7) + Ethyl 4-bromobenzoate (5798-75-4) → 4-cyclopropyl-benzoic acid ethyl ester (35391-85-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

DOI:10.1021/jo702377h

Reference yield: 85.0%

tricyclopropylbismuthane (925430-09-7) + 4-iodobenzoic acid ethyl ester (51934-41-9) → 4-cyclopropyl-benzoic acid ethyl ester (35391-85-6)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

DOI:10.1021/jo702377h

Reference yield: 80.0%

Ethyl 4-bromobenzoate (5798-75-4) + cyclopropyl bromide (4333-56-6,130561-87-4) → 4-cyclopropyl-benzoic acid ethyl ester (35391-85-6)

Guidance literature:

With potassium hexafluorophosphate; bis(1,3-bis((4-methyl-2-pyridyl)imino)isoindolinato)nickel(II); C₂₂H₁₉N₅NiO₂; triphenylphosphine; In N,N-dimethyl acetamide; at 50 ℃; Inert atmosphere; Electrolysis; Sealed tube;

DOI:10.1021/jacs.0c01475

upstream raw materials:

ethanol

4-cyclopropylbenzenecarboxylic acid chloride

4-cyclopropylbenzoic acid

bis(triphenylphosphine)palladium(II) chloride

Downstream raw materials:

4-cyclopropyl-benzenemethanol

Refernces

• 1、 Hamby, Taylor B.,Sevov, Christo S.,Truesdell, Blaise L.. "General C(sp2)-C(sp3) Cross-Electrophile Coupling Reactions Enabled by Overcharge Protection of Homogeneous Electrocatalysts". supporting information. p. 5884 - 5893. Retrieved 2020/04/10.
• 2、 -. "N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists". . . Retrieved 2008/06/13.