1,2,3,4-Tetrahydroquinolin-8-ol

Base Information

• Chemical Name: 1,2,3,4-Tetrahydroquinolin-8-ol
• CAS No.: 6640-50-2
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2933499090
• European Community (EC) Number: 675-339-6
• NSC Number: 48890
• DSSTox Substance ID: DTXSID00287096
• Nikkaji Number: J1.730.850E
• Wikidata: Q72505754
• Mol file: 6640-50-2.mol

Synonyms:6640-50-2;1,2,3,4-tetrahydroquinolin-8-ol;8-hydroxy-1,2,3,4-tetrahydroquinoline;1,2,3,4-tetrahydro-8-hydroxyquinoline;1,2,3,4-Tetrahydro-quinolin-8-ol;8-Quinolinol, 1,2,3,4-tetrahydro-;1,2,3,4-tetrahydro-8-quinolinol;MFCD02656029;NSC48890;Oprea1_810842;SCHEMBL327043;DTXSID00287096;WYKWUPMZBGOFOV-UHFFFAOYSA-N;HMS1685G10;NSC-48890;STK771614;AKOS000122477;AB89728;AC-9571;CS-W002942;CS-W003392;ET-0012;SY010056;METHYL3-(3-BORONOPHENYL)PROPIONATE;8-HYDROXY-1234-TETRAHYDROQUINOLINE;AM20061046;BB 0216335;FT-0606193;EN300-07172;1,2,3,4-Tetrahydroquinolin-8-ol, AldrichCPR;A26301;AF-399/25108090;J-519264;J-519441;Z57001601

Chemical Property of 1,2,3,4-Tetrahydroquinolin-8-ol

Chemical Property:

• Melting Point: 121-121.5 °C
• Boiling Point: 300.9°Cat760mmHg
• PKA: 11.17±0.20(Predicted)
• Flash Point: 159.1°C
• PSA: 32.26000
• Density: 1.141g/cm³
• LogP: 1.88830
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

8-Hydroxy-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-52

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C(=CC=C2)O)NC1

Technology Process of 1,2,3,4-Tetrahydroquinolin-8-ol

There total 13 articles about 1,2,3,4-Tetrahydroquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

8-quinolinol (148-24-3,24804-14-6) → 1,2,3,4-tetrahydroquinolin-8-ol (6640-50-2)

Guidance literature:

With C₂₆H₂₉ClIrNO₃; hydrogen; In 2,2,2-trifluoroethanol; at 20 ℃; for 3h; under 760.051 Torr;

DOI:10.1039/c3cc44567d

Reference yield: 90.0%

1-(pyrimidin-2-yl)-1,2,3,4-tetrahydroquinolin-8-ol → 1,2,3,4-tetrahydroquinolin-8-ol (6640-50-2)

Guidance literature:

With sodium t-butanolate; In dimethyl sulfoxide; at 130 ℃; for 12h;

DOI:10.1021/acs.orglett.8b02926

Reference yield: 72.0%

5-Chloro-8-hydroxyquinoline (130-16-5) → 1,2,3,4-tetrahydroquinolin-8-ol (6640-50-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 24.5h; under 760.051 Torr; Solvent;

DOI:10.1248/cpb.c21-00127

upstream raw materials:

8-quinolinol

sulfuric acid

water

8-methoxy-1,2,3,4-tetrahydroquinoline

Downstream raw materials:

1-benzoyl-1,2,3,4-tetrahydro-8-quinolinol

2-Thioxo-5,6-dihydro-4H-oxazolo<5,4,3-ij>-chinolin

(8-(2-hydroxy-3-(isopropylamino)propoxy)-3,4-dihydroquinolin-1(2H)-yl)(pyridin-3-yl)methanone

1-nicotinoyl-8-hydroxy-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 Huang, Songtao,Li, Aiyuan,Shao, Fangjun,Wang, Jianguo,Wei, Zhongzhe,Yao, Zihao,Zhao, Zijiang,Zhou, Qiang. "Engineering the geometric and electronic structure of Ru: Via Ru-TiO2interaction for enhanced selective hydrogenation". . p. 1005 - 1016. Retrieved 2022/02/17.
• 2、 Yun, Ruirui,Zhang, Beibei,Qiu, Chuang,Ma, Ziwei,Zhan, Feiyang,Sheng, Tian,Zheng, Baishu. "Encapsulating Cobalt into N-Doping Hollow Frameworks for Efficient Cascade Catalysis". supporting information. p. 9757 - 9761. Retrieved 2021/06/30.