8-Methoxy-1,2,3,4-tetrahydroquinoline

Base Information

• Chemical Name: 8-Methoxy-1,2,3,4-tetrahydroquinoline
• CAS No.: 53899-17-5
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2933499090
• European Community (EC) Number: 837-373-1
• DSSTox Substance ID: DTXSID90409447
• Nikkaji Number: J1.864.341C
• Wikidata: Q82215271
• Mol file: 53899-17-5.mol

Synonyms:8-methoxy-1,2,3,4-tetrahydroquinoline;53899-17-5;8-methoxy-1,2,3,4-tetrahydro-quinoline;8-methoxy-1,2,3,4-tetrahydroquinoline hydrobromide;METHYLENEDIFORMAMIDOXIME;SCHEMBL2333682;DTXSID90409447;MFCD07800307;AKOS000124110;BS-13636;CS-0199155;FT-0648617;Quinoline, 1,2,3,4-tetrahydro-8-methoxy-;EN300-35216;A1-02968;F8889-6059;Z285175138

Chemical Property of 8-Methoxy-1,2,3,4-tetrahydroquinoline

Chemical Property:

• Vapor Pressure: 0.00117mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 299.7°C at 760 mmHg
• Flash Point: 115.1°C
• PSA: 21.26000
• Density: 1.044g/cm³
• LogP: 2.19130
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

8-Methoxy-1,2,3,4-tetrahydro-quinoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1NCCC2
• Uses: 8-Methoxy-1,2,3,4-tetrahydroquinoline is used as a reactant in the catalytic aerobic dehydrogenation of nitrogen heterocycles.

Technology Process of 8-Methoxy-1,2,3,4-tetrahydroquinoline

There total 12 articles about 8-Methoxy-1,2,3,4-tetrahydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

8-methoxyquinoline (938-33-0) → 5,6,7,8-tetrahydroquinoline (10500-57-9) + 8-methoxy-1,2,3,4-tetrahydroquinoline (53899-17-5) + 8-methoxy-5,6,7,8-tetrahydroquinoline (75414-07-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In trifluoroacetic acid;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 8-methoxy-3-(2-methoxy-benzenesulfonyl)-[2]quinolylamine → 8-methoxy-1,2,3,4-tetrahydroquinoline (53899-17-5) + 2-Methoxybenzenethiol (7217-59-6)

Guidance literature:

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 8-methoxy-3-(toluene-4-sulfonyl)-[2]quinolylamine → 8-methoxy-1,2,3,4-tetrahydroquinoline (53899-17-5) + para-thiocresol (106-45-6)

Guidance literature:

upstream raw materials:

8-methoxyquinoline

hydrogenchloride

acetic acid

Downstream raw materials:

8-hydroxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester

1,2,3,4-tetrahydroquinolin-8-ol

8-methoxyquinoline

[2-(2,5-dichloro-phenoxy)-pyridin-3-yl]-(8-methoxy-3,4-dihydro-2H-quinolin-1-yl)-methanone

Refernces