2-Chloro-5-iodo-4-pyridinamine

Base Information

• Chemical Name: 2-Chloro-5-iodo-4-pyridinamine
• CAS No.: 800402-12-4
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.458
• Hs Code.: 2933399090
• Mol file: 800402-12-4.mol

Synonyms:2-chloro-5-iodopyridin-4-amine;

Chemical Property of 2-Chloro-5-iodo-4-pyridinamine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 126-127°
• Boiling Point: 367.751oC at 760 mmHg
• PKA: 2.96±0.42(Predicted)
• Flash Point: 176.21oC
• PSA: 38.91000
• Density: 2.139g/cm3
• LogP: 2.50300
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-iodo-4-pyridinamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-iodo-4-pyridinamine

There total 5 articles about 2-Chloro-5-iodo-4-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.1%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4)

Guidance literature:

With N-iodo-succinimide; In acetonitrile; at 70 ℃; for 16h; Inert atmosphere;

Reference yield: 49.7%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0) + 2-chloro-3,5-diiodopyridin-4-amine (1171919-00-8)

Guidance literature:

With potassium acetate; Iodine monochloride; In acetic acid; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.03.019

Reference yield: 45.0%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3,5-diiodopyridin-4-amine (1171919-00-8)

Guidance literature:

With sodium acetate; Iodine monochloride; acetic acid; at 60 ℃; for 2h;

DOI:10.1021/acs.jmedchem.5b01545

upstream raw materials:

4-Amino-2-chloropyridine

dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane

3-chlorobenzofuran[3,2-c]pyridine

phenylboronic acid

Downstream raw materials:

6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid

Refernces

• 1、 -. "PYRIMIDINE OR PYRIDOPYRIDONE COMPOUND AND APPLICATION THEREOF". Paragraph 0046; 0069. . Retrieved 2018/11/21.
• 2、 -. "HETEROARYL SUBSTITUTED AMINOPYRIDINE COMPOUNDS". Page/Page column 171-172. . Retrieved 2017/01/09.