2-CHLORO-3-IODOPYRIDIN-4-AMINE

Base Information

• Chemical Name: 2-CHLORO-3-IODOPYRIDIN-4-AMINE
• CAS No.: 909036-46-0
• Molecular Formula: C5H4ClIN2
• Molecular Weight: 254.458
• Hs Code.: 2933399090
• Mol file: 909036-46-0.mol

Synonyms:2-CHLORO-3-IODOPYRIDIN-4-AMINE;2-Chloro-3-iodo-4-aminopyridine;4-Amino-2-chloro-3-iodopyridine;4-PyridinaMine, 2-chloro-3-iodo-

Chemical Property of 2-CHLORO-3-IODOPYRIDIN-4-AMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 116-117℃
• Refractive Index: 1.708
• Boiling Point: 377.042 °C at 760 mmHg
• PKA: 2.96±0.42(Predicted)
• Flash Point: 181.829 °C
• PSA: 38.91000
• Density: 2.139g/cm³
• LogP: 2.50300
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive.: Light Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3-iodopyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-3-iodo-4-pyridinamine can be used as a useful synthetic intermediate.

Technology Process of 2-CHLORO-3-IODOPYRIDIN-4-AMINE

There total 3 articles about 2-CHLORO-3-IODOPYRIDIN-4-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.7%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0) + 2-chloro-3,5-diiodopyridin-4-amine (1171919-00-8)

Guidance literature:

With potassium acetate; Iodine monochloride; In acetic acid; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.03.019

Reference yield: 45.0%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0)

Guidance literature:

With sodium acetate trihydrate; Iodine monochloride; acetic acid; at 70 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.01.040

Reference yield: 41.0%

4-Amino-2-chloropyridine (14432-12-3) → 2-chloro-4-amino-5-iodopyridine (800402-12-4) + 2-chloro-3-iodo-pyridin-4-ylamine (909036-46-0)

Guidance literature:

With sodium acetate; Iodine monochloride; In acetic acid; at 70 ℃; for 3.5h;

upstream raw materials:

4-Amino-2-chloropyridine

Refernces

• 1、 -. "Organic compound, electroluminescent device containing organic compound and applications of electroluminescent device". Paragraph 0115-0117. . Retrieved 2020/06/17.
• 2、 Jose, Gilish,Suresha Kumara, Tholappanavara H.,Sowmya, Haliwana B.V.,Sriram, Dharmarajan,Guru Row, Tayur N.,Hosamani, Amar A.,More, Sunil S.,Janardhan, Bhavya,Harish,Telkar, Sandeep,Ravikumar, Yalegara Siddappa. "Synthesis, molecular docking, antimycobacterial and antimicrobial evaluation of new pyrrolo[3,2-c]pyridine Mannich bases". . p. 275 - 288. Retrieved 2017/03/24.