1-(3-Methoxyphenyl)-3-phenylurea

Base Information

• Chemical Name: 1-(3-Methoxyphenyl)-3-phenylurea
• CAS No.: 13142-83-1
• Molecular Formula: C14H14 N2 O2
• Molecular Weight: 242.277
• NSC Number: 164410
• DSSTox Substance ID: DTXSID30304164
• Wikidata: Q82049898
• ChEMBL ID: CHEMBL464265
• Mol file: 13142-83-1.mol

Synonyms:1-(3-methoxyphenyl)-3-phenylurea;13142-83-1;NSC 164410;NSC164410;Oprea1_045063;CHEMBL464265;SCHEMBL14442613;DTXSID30304164;N-(3-methoxyphenyl)-N'-phenylurea;1-(M-ANISYL)-3-PHENYLUREA;STL012280;N-(3-Methoxyphenyl)-N'-phenyl-urea;AKOS001408348;N-(3-methoxyphenyl)-N' -phenyl urea;NSC-164410;Z44586569

Chemical Property of 1-(3-Methoxyphenyl)-3-phenylurea

Chemical Property:

• Vapor Pressure: 0.00112mmHg at 25°C
• Boiling Point: 300.5°Cat760mmHg
• Flash Point: 135.5°C
• Density: 1.249g/cm³
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 265

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1)NC(=O)NC2=CC=CC=C2

Technology Process of 1-(3-Methoxyphenyl)-3-phenylurea

There total 8 articles about 1-(3-Methoxyphenyl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

m-Anisidine (536-90-3,918666-97-4) + 3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) → N-(3-methoxyphenyl)-N'-phenyl-urea (13142-83-1)

Guidance literature:

With sodium acetate; In methanol; at 60 ℃; for 2h;

Reference yield: 83.0%

(1H-benzo[d][1,2,3]triazol-1-yl)(3-methoxyphenyl)methanone + aniline (62-53-3) → N-(3-methoxyphenyl)-N'-phenyl-urea (13142-83-1)

Guidance literature:

With trimethylsilylazide; triethylamine; In toluene; at 110 ℃; for 1h; Sealed tube;

DOI:10.1055/s-0039-1689937

Reference yield: 76.5%

aniline (62-53-3) + 3-methoxyphenyl isocyanate (18908-07-1) → N-(3-methoxyphenyl)-N'-phenyl-urea (13142-83-1)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2016.09.083

upstream raw materials:

m-Anisidine

phenyl isocyanate

benzoyl azide

aniline

Downstream raw materials:

1-(3-hydroxyphenyl)-3-phenylurea

Refernces

• 1、 Agrahari, Anand K.,Singh, Anoop S.,Singh, Sumit K.,Tiwari, Vinod K.,Yadav, Mangal S.. "An Improved Synthesis of Urea Derivatives from N -Acylbenzotriazole via Curtius Rearrangement". . p. 3443 - 3450. Retrieved 2019/09/07.
• 2、 Sribalan, Rajendran,Sangili, Arumugam,Banuppriya, Govindharasu,Padmini, Vediappen. "An efficient synthesis of nitrile, tetrazole and urea from carbonyl compounds". . p. 3414 - 3421. Retrieved 2017/07/13.