3-(3-Hydroxyphenyl)-1-phenylurea

Base Information

• Chemical Name: 3-(3-Hydroxyphenyl)-1-phenylurea
• CAS No.: 13142-80-8
• Molecular Formula: C₁₃H₁₂N₂O₂
• Molecular Weight: 228.25
• European Community (EC) Number: 841-555-6
• ChEMBL ID: CHEMBL268253
• Mol file: 13142-80-8.mol

Synonyms:3-(3-hydroxyphenyl)-1-phenylurea;13142-80-8;1-(3-hydroxyphenyl)-3-phenylurea;CHEMBL268253;SCHEMBL7098404;AKOS008961269;N-(3-HYDROXYPHENYL)-N'-PHENYLUREA;CS-0237338;EN300-182535

Chemical Property of 3-(3-Hydroxyphenyl)-1-phenylurea

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 228.089877630
• Heavy Atom Count: 17
• Complexity: 252

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)NC2=CC(=CC=C2)O

Technology Process of 3-(3-Hydroxyphenyl)-1-phenylurea

There total 3 articles about 3-(3-Hydroxyphenyl)-1-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.8%

N-(3-methoxyphenyl)-N'-phenyl-urea (13142-83-1) → 1-(3-hydroxyphenyl)-3-phenylurea (13142-80-8)

Guidance literature:

With hydrogen bromide; acetic acid; at 70 ℃;

DOI:10.1016/j.ejmech.2016.09.083

Reference yield:

aniline (62-53-3) → 1-(3-hydroxyphenyl)-3-phenylurea (13142-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: hydrogen bromide; acetic acid / 70 °C

With hydrogen bromide; acetic acid; In dichloromethane;

DOI:10.1016/j.ejmech.2016.09.083

Reference yield:

1-(3-hydroxyphenyl)urea (701-82-6) + aniline (62-53-3) → 1-(3-hydroxyphenyl)-3-phenylurea (13142-80-8)

Guidance literature:

at 180 - 190 ℃;

upstream raw materials:

1-(3-hydroxyphenyl)urea

aniline

N-(3-methoxyphenyl)-N'-phenyl-urea

Downstream raw materials:

1-[3-(1-Amino-4-hydroxy-9,10-dioxo-9,10-dihydro-anthracen-2-yloxy)-phenyl]-3-phenyl-urea

Refernces