3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid

Base Information

• Chemical Name: 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid
• CAS No.: 18372-11-7
• Molecular Formula: C36H38 N4 O8
• Molecular Weight: 654.72
• Mol file: 18372-11-7.mol

Synonyms:2,7,13,18-Porphinetetrapropionicacid, 3,8,12,17-tetramethyl- (8CI); Coproporphyrin IV (6CI)

Chemical Property of 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 1264.7°Cat760mmHg
• Flash Point: 718.7°C
• PSA: 205.50000
• Density: 1.366g/cm³
• LogP: 2.98470

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid

There total 2 articles about 3,8,12,17-tetramethyl-21H,23H-Porphine-2,7,13,18-tetrapropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H25N3O8*H(1+) → coproporphyrin-II (3082-03-9) + coproporphyrin lV (18372-11-7) + coproporphyrin-III (14643-66-4) + coproporphyrin I (531-14-6)

Guidance literature:

With hydrogenchloride; phosphate buffer; deaminase-cosynthetase from Euglena gracilis; Mechanism; Product distribution; multistep reaction; other products ratio with enzyme solution which had been heated (96 deg C, 5 min); labelling experiments; mechanism of biosynthesis of uroporphyrinogens;

DOI:10.1039/P19810002779

Reference yield:

coproporphyrinogen lV (59969-39-0) → protoporphyrin Xlll (59969-38-9) + protoporphyrin IX (553-12-8) + coproporphyrin lV (18372-11-7) + harderoporphyrin-VII

Guidance literature:

at 38 ℃; for 22h; Product distribution; beef-liver mitochondria, 0.2M Tris-HCl buffer (pH 7.8); incubation time and concentration dependence;

Reference yield:

coproporphyrin lV (18372-11-7) → 3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester (5522-66-7,6164-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. KOH, 3percent sodium amalgam / 0.08 h / dark

2: 2.) H₂SO₄ / 1.) beef-liver mitochondria, 0.2M Tris-HCl buffer (pH 7.8), 38 deg C, 22 h, 2.) 25 deg C

With potassium hydroxide; sodium amalgam; sulfuric acid;

upstream raw materials:

coproporphyrinogen lV

Downstream raw materials:

3,3'-(3,7,12,17-tetramethyl-8,13-divinyl-21H,23H-porphine-2,18-diyl)-bis-propionic acid dimethyl ester

Refernces

• 1、 Battersby, Alan R.,Hamilton, Andrew D.,McDonald, Edward,Mombelli, Luisa,Wong, Oi-Hoong. "Biosynthesis of Porphyrins and Related Macrocycles. Part 13. Structure of the Protoporphyrin Isomer derived from Coproporphyrinogen lV by the Action of Beef-Liver Coproporphyrinogenase: Synthesis of Protoporphyrin Xlll". . p. 1283 - 1289. Retrieved 2007/10/02.