3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid

Base Information

• Chemical Name: 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid
• CAS No.: 531-14-6
• Molecular Formula: C36H38N4O8
• Molecular Weight: 654.72
• Mol file: 531-14-6.mol

Synonyms:3,8,13,18-Tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid;coproporphyrin I-3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid;Coproporphyrin I;3,8,13,18-tetramethyl-21H,23H-porphyrin 2,7,12,17-tetrapropionic acid;coproporphyrin-I tetracarboxylic acid;coproporphyrine I;

Chemical Property of 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid

Chemical Property:

• Boiling Point: 1264.7°Cat760mmHg
• Flash Point: 718.7°C
• PSA: 205.50000
• Density: 1.366g/cm³
• LogP: 3.09360
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%min ^*data from raw suppliers

CoproporphyrinI,85%(contains13%Coproporphyrinlll) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Coproporphyrin I is a porphyrin, a naturally occuring aromatic heterocyclic marcomolecule. The ratio of Coproporphyrin I and Coproporphyrin III provides a useful biochemical marker for distinguishing familial and sporadic porphyria cutanea tarda. Coproporphyrin I also serve as a biomarker of environmental toxicity and susceptibility in autism.

Technology Process of 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid

There total 31 articles about 3,8,13,18-tetramethyl-21H,23H-porphine-2,7,12,17-tetrapropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-hydroxymethyl-4-methyl-1H-pyrrol-3-yl)-propionic acid (872535-45-0) → coproporphyrin I (531-14-6)

Guidance literature:

3-(2-hydroxymethyl-4-methyl-1H-pyrrol-3-yl)-propionic acid; With porphobilinogen deaminase; potassium chloride; magnesium chloride; In various solvent(s); at 37 ℃; for 3h; pH=7.8; Enzymatic reaction;

With oxygen; In various solvent(s); at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.10.063

Reference yield:

3-(2-hydroxymethyl-4-methyl-1H-pyrrol-3-yl)-propionic acid (872535-45-0) → coproporphyrin III (14643-66-4) + coproporphyrin I (531-14-6)

Guidance literature:

3-(2-hydroxymethyl-4-methyl-1H-pyrrol-3-yl)-propionic acid; With Uro'gen III synthase; potassium chloride; magnesium chloride; In various solvent(s); at 37 ℃; pH=7.5 - 8.0; Enzymatic reaction;

With oxygen; In various solvent(s); at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2005.10.063

Reference yield:

uroporphyrin I octamethyl ester (10170-03-3) → coproporphyrin I (531-14-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1093/sp/8.2.210

upstream raw materials:

formic acid

3-(4-methyl-pyrrol-3-yl)-propionic acid

chloromethyl methyl ether

4-(2-carboxyethyl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester

Downstream raw materials:

coproporphyrin I methyl ester

Refernces

• 1、 Koest, H.-P.,Benedikt, E.,Cmiehl, E.,Schneider, S.. "SYNTHESIS AND CHARACTERIZATION OF COPROBILIVERDIN III, A NEW MODEL CHROMOPHORE". . p. 3975 - 3978. Retrieved 1983.
• 2、 Wang, Yuesong,Gatti, Paula,Sadilek, Martin,Scott, C. Ronald,Turecek, Frantisek,Gelb, Michael H.. "Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase". . p. 2599 - 2605. Retrieved 2008/09/20.