3-Methoxypyridin-4-amine

Base Information

• Chemical Name: 3-Methoxypyridin-4-amine
• CAS No.: 52334-90-4
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.142
• Hs Code.: 2933399090
• European Community (EC) Number: 800-334-4
• DSSTox Substance ID: DTXSID60200362
• Nikkaji Number: J2.242.341J
• Wikidata: Q72438975
• Mol file: 52334-90-4.mol

Synonyms:3-methoxy-4-aminopyridine

Chemical Property of 3-Methoxypyridin-4-amine

Chemical Property:

• Vapor Pressure: 0.00442mmHg at 25°C
• Melting Point: 94.5-95.5 °C
• Refractive Index: 1.56
• Boiling Point: 277.8 °C at 760 mmHg
• PKA: 8.11±0.10(Predicted)
• Flash Point: 121.8 °C
• PSA: 48.14000
• Density: 1.14 g/cm³
• LogP: 1.25360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 124.063662883
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

98% ^*data from raw suppliers

3-Methoxy-4-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=CN=C1)N
• Uses: 3-Methoxy-4-pyridinamine, is a building block used in various chemical synthesis.

Technology Process of 3-Methoxypyridin-4-amine

There total 4 articles about 3-Methoxypyridin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methoxy-4-nitropyridine 1-oxide (19355-04-5) → 4-amino-3-methoxy pyridine (52334-90-4)

Guidance literature:

With hydrogen; nickel; In methanol; at 40 ℃; for 3h; under 30400 Torr;

DOI:10.1016/j.tetlet.2005.06.173

Reference yield:

ammonium hydroxide (1336-21-6) + 3-methoxy-4-nitropyridine 1-oxide (19355-04-5) + dichloromethane (75-09-2) → 4-amino-3-methoxy pyridine (52334-90-4)

Guidance literature:

aluminum nickel; In methanol;

Reference yield:

3-methoxypyridine N-oxide (14906-61-7) → 4-amino-3-methoxy pyridine (52334-90-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / HNO₃ / acetic acid / 20 h / 20 - 80 °C

2: 98 percent / H₂ / Raney Ni / methanol / 3 h / 40 °C / 30400 Torr

With hydrogen; nitric acid; nickel; In methanol; acetic acid;

DOI:10.1016/j.tetlet.2005.06.173

upstream raw materials:

3-methoxy-4-nitropyridine 1-oxide

3-methoxypyridine N-oxide

3-methoxypyridine

ammonium hydroxide

Downstream raw materials:

4-amino-3-methoxy-5-nitropyridine

phenyl (3-methoxypyridin-4-yl)carbamate

[2-(5-chloro-2-fluoro-phenyl)-quinolin-4-yl]-(3-methoxy-pyridin-4-yl)-amine

4-amino-3-hydroxy pyridine

Refernces

• 1、 Wu, Zong-Quan,Jiang, Xi-Kui,Li, Zhan-Ting. "Hydrogen bonding-mediated self-assembly of square and triangular metallocyclophanes". . p. 8067 - 8070. Retrieved 2007/10/03.
• 2、 Barraclough,Black,Cambridge,Collard,Firmin,Gerskowitch,Glen,Giles,Hill,Hull,Iyer,King,Kneen,Lindon,Nobbs,Randall,Shah,Smith,Vine,et al.. "Inotropic 'A' ring substituted sulmazole and isomazole analogues". . p. 2231 - 2239. Retrieved 2007/10/02.