(2-bromo-4-methylphenyl)methanol

Base Information

• Chemical Name: (2-bromo-4-methylphenyl)methanol
• CAS No.: 824-53-3
• Molecular Formula: C8H9BrO
• Molecular Weight: 201.063
• Hs Code.: 2906290090
• Mol file: 824-53-3.mol

Synonyms:(2-bromo-4-methyl-phenyl)methanol;Benzenemethanol,2-bromo-4-methyl;2-bromo-4-methylbenzyl alcohol;2-Brom-4-methyl-benzylalkohol;

Chemical Property of (2-bromo-4-methylphenyl)methanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.24980

Purity/Quality:

95% ^*data from raw suppliers

(2-Bromo-4-methylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (2-Bromo-4-methylphenyl)methanol is used in preparation of 6,7-Dihydro-5H-diphenyl[a,c]cyclohepten-5-one compounds.

Technology Process of (2-bromo-4-methylphenyl)methanol

There total 5 articles about (2-bromo-4-methylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-4-methylbenzaldehyde (824-54-4) → 2,6-dibromo-4-methylbenzyl alcohol (824-53-3) + 2-bromo-4-methylbenzoic acid (7697-27-0)

Guidance literature:

2-bromo-4-methylbenzaldehyde; With potassium hydroxide; for 0.0833333h; Milling; Inert atmosphere; Sealed tube; Green chemistry;

With hydrogenchloride; In water; for 0.0833333h; Green chemistry;

DOI:10.1039/c8gc02481b

Reference yield: 98.0%

2-bromo-4-methylbenzaldehyde (824-54-4) → 2,6-dibromo-4-methylbenzyl alcohol (824-53-3)

Guidance literature:

2-bromo-4-methylbenzaldehyde; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.583333h;

With hydrogenchloride; In methanol; at 20 ℃; for 0.25h;

DOI:10.1039/c0ob00526f

Reference yield: 95.0%

2-bromo-4-methylbenzoic acid (7697-27-0) → 2,6-dibromo-4-methylbenzyl alcohol (824-53-3)

Guidance literature:

2-bromo-4-methylbenzoic acid; With dimethyl sulfide borane; In tetrahydrofuran; for 2h; Reflux;

With sodium hydroxide; In tetrahydrofuran; water; for 0.5h;

DOI:10.1021/ja805598s

upstream raw materials:

2-bromo-4-methylbenzoic acid

2-bromo-4-methylbenzaldehyde

2,6-dibromo-4-methylbenzaldehyde

Downstream raw materials:

2-(2-bromo-4-methylbenzyl)-2-nitrocyclohexanone

2-(2-bromo-4-methylbenzyl)-2-nitrocycloheptanone

2-(2-bromo-4-methylbenzyl)-2-nitrocyclooctanone

2-bromo-1-iodomethyl-4-methylbenzene

Refernces

• 1、 Chacón-Huete,Messina,Chen,Cuccia,Ottenwaelder,Forgione. "Solvent-free mechanochemical oxidation and reduction of biomass-derived 5-hydroxymethyl furfural". . p. 5261 - 5265. Retrieved 2018/12/05.
• 2、 Watanabe, Kohei,Mino, Takashi,Hatta, Chikako,Ito, Shisei,Sakamoto, Masami. "Hydrazone-palladium catalyzed annulation of 1-allyl-2-bromobenzene derivatives with internal alkynes". supporting information. p. 11645 - 11650. Retrieved 2015/12/08.