(fluoromethoxy)benzene

Base Information

• Chemical Name: (fluoromethoxy)benzene
• CAS No.: 87453-27-8
• Molecular Formula: C7H7FO
• Molecular Weight: 126.13
• Mol file: 87453-27-8.mol

Synonyms:

Chemical Property of (fluoromethoxy)benzene

Chemical Property:

• Vapor Pressure: 4.01mmHg at 25°C
• Boiling Point: 154.8°Cat760mmHg
• Flash Point: 50.9°C
• Density: 1.06g/cm³

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (fluoromethoxy)benzene

There total 15 articles about (fluoromethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert-butyl 2-phenoxyethaneperoxoate (5789-77-5) + N-fluorobis(benzenesulfon)imide (133745-75-2) → dibenzenesulfonamide (2618-96-4) + fluoromethyl phenyl ether (87453-27-8)

Guidance literature:

In [D₃]acetonitrile; at 110 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

DOI:10.1021/ja211679v

Reference yield: 86.0%

R32 (593-70-4) + phenol (108-95-2,27073-41-2) → fluoromethyl phenyl ether (87453-27-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 3h;

DOI:10.1002/cmdc.201402555

Reference yield: 84.0%

2-phenoxyacetic acid (122-59-8) → fluoromethyl phenyl ether (87453-27-8)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; Selectfluor; In acetonitrile; for 3h; Reagent/catalyst; Inert atmosphere; Irradiation;

DOI:10.1002/ejoc.201500038

upstream raw materials:

benzyl alcohol

2-phenoxyacetic acid

(chloromethoxy)benzene

methyl thiomethyl ether of phenol

Downstream raw materials:

(pentyloxy)benzene

allyl phenyl ether

Refernces

• 1、 Pieber, Bartholom?us,Shalom, Menny,Antonietti, Markus,Seeberger, Peter H.,Gilmore, Kerry. "Continuous Heterogeneous Photocatalysis in Serial Micro-Batch Reactors". supporting information. p. 9976 - 9979. Retrieved 2018/03/21.
• 2、 Xing, Li,Blakemore, David C.,Narayanan, Arjun,Unwalla, Ray,Lovering, Frank,Denny, R. Aldrin,Zhou, Huanyu,Bunnage, Mark E.. "Fluorine in drug design: A case study with fluoroanisoles". . p. 715 - 726. Retrieved 2015/04/14.