Methyl 4-(2H-1,2,3,4-tetrazol-5-yl)benzoate

Base Information

• Chemical Name: Methyl 4-(2H-1,2,3,4-tetrazol-5-yl)benzoate
• CAS No.: 82544-82-9
• Molecular Formula: C9H8N4O2
• Molecular Weight: 204.188
• Hs Code.: 2916310090
• Mol file: 82544-82-9.mol

Synonyms:

Chemical Property of Methyl 4-(2H-1,2,3,4-tetrazol-5-yl)benzoate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-(1H-Tetrazol-5-yl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-(2H-1,2,3,4-tetrazol-5-yl)benzoate

There total 10 articles about Methyl 4-(2H-1,2,3,4-tetrazol-5-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-cyanobenzoic acid methyl ester (1129-35-7) → 5-tetrazole (82544-82-9)

Guidance literature:

With sodium azide; triethylamine hydrochloride; In toluene; at 110 ℃; for 24h;

DOI:10.1021/ol402645q

Reference yield: 96.0%

4-cyanobenzoic acid methyl ester (1129-35-7) → methyl 4-(1H-tetrazole-5-yl)benzoate (82544-82-9)

Guidance literature:

4-cyanobenzoic acid methyl ester; With sodium azide; triethylamine hydrochloride; In toluene; at 100 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield: 92.0%

4-cyanobenzoic acid methyl ester (1129-35-7) + trimethylsilylazide (4648-54-8) → methyl 4-(1H-tetrazole-5-yl)benzoate (82544-82-9)

Guidance literature:

With tetrabutylammonium fluoride monohydrate; In toluene; for 5h; Reflux;

DOI:10.1016/j.ejmech.2018.10.021

upstream raw materials:

4-cyanobenzoic acid methyl ester

4-cyanobenzoic Acid

methanol

4-(1H-tetrazol-5-yl)benzoic acid

Downstream raw materials:

methyl 4-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)benzoate

methyl 4-(5-methyl-1,3,4-oxadiazol-2-yl)benzoate

Refernces

• 1、 Padmaja,Chanda, Kaushik. "A robust and recyclable ionic liquid-supported copper(II) catalyst for the synthesis of 5-substituted-1H-tetrazoles using microwave irradiation". . p. 1307 - 1317. Retrieved 2019/11/14.
• 2、 Khalifeh, Reza,Khalili, Dariush,Rastegar, Najme. "Highly active and reusable cu/c catalyst for synthesis of 5-substituted 1h-tetrazoles starting from aromatic aldehydes". . p. 1044 - 1052. Retrieved 2021/06/07.