5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone

Base Information

• Chemical Name: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone
• CAS No.: 825633-93-0
• Molecular Formula: C11H9IN2O
• Molecular Weight: 312.11
• Hs Code.: 2933990090
• Mol file: 825633-93-0.mol

Synonyms:2-benzyl-5-iodopyridazin-3(2H)-one

Chemical Property of 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone

Chemical Property:

• Melting Point: 136-137℃
• Boiling Point: 370℃
• Flash Point: 178℃
• PSA: 34.89000
• Density: 1.70
• LogP: 1.89620
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Benzyl-5-iodopyridazin-3(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Benzyl-5-iodopyridazin-3(2H)-one is a reactant used in high temperature Pd-catalyzed intramolecular direct arylations.

Technology Process of 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone

There total 3 articles about 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-benzyl-4,5-dichloro-3(2H)-pyridazinone (41933-33-9) → 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one (825633-93-0)

Guidance literature:

With hydrogen iodide; for 24h; Heating;

DOI:10.1016/j.tet.2004.10.014

Reference yield:

benzyl bromide (100-39-0) + 5-iodo-2,3-dihydropyridazin-3-one (825633-94-1) → 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one (825633-93-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

benzyl bromide (100-39-0) → 2-benzyl-5-iodo-2,3-dihydropyridazin-3-one (825633-93-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; tetrabutylammomium bromide / acetonitrile / 2 h / Inert atmosphere; Reflux

2: hydrogen iodide / water / 16 h / Reflux

With tetrabutylammomium bromide; hydrogen iodide; potassium carbonate; In water; acetonitrile;

upstream raw materials:

2-benzyl-4,5-dichloro-3(2H)-pyridazinone

benzyl bromide

5-iodo-2,3-dihydropyridazin-3-one

Downstream raw materials:

2-benzyl-5-vinylpyridazin-3(2H)-one

2-benzyl-5-(4-fluorophenyl)pyridazin-3(2H)-one

2-benzyl-5-{[2-bromo-4-(trifluoromethoxy)phenyl]amino}pyridazin-3(2H)-one

2-benzyl-5-{[2-bromo-4-methylphenyl]amino}pyridazin-3(2H)-one

Refernces

• 1、 -. "PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS". Paragraph 0174; 0175. . Retrieved 2016/04/09.
• 2、 -. "IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS". Page/Page column 25-26. . Retrieved 2010/08/08.