2-(4-NITROPHENYL)ACETOHYDRAZIDE

Base Information

• Chemical Name: 2-(4-NITROPHENYL)ACETOHYDRAZIDE
• CAS No.: 6144-81-6
• Molecular Formula: C8H9 N3 O3
• Molecular Weight: 195.178
• Hs Code.: 2928000090
• Mol file: 6144-81-6.mol

Synonyms:Aceticacid, (p-nitrophenyl)-, hydrazide (7CI,8CI); (4-Nitrophenyl)acetic acidhydrazide; 4-Nitrophenylacetylhydrazine; NSC 147107

Chemical Property of 2-(4-NITROPHENYL)ACETOHYDRAZIDE

Chemical Property:

• Vapor Pressure: 2E-09mmHg at 25°C
• Boiling Point: 481.4°C at 760 mmHg
• Flash Point: 244.9°C
• PSA: 100.94000
• Density: 1.358g/cm³
• LogP: 1.74160

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-nitrophenyl)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-NITROPHENYL)ACETOHYDRAZIDE

There total 6 articles about 2-(4-NITROPHENYL)ACETOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + 4-nitrobenzeneacetic acid (104-03-0) → 4-nitrophenylacetic acid hydrazide (6144-81-6)

Guidance literature:

ethanol; 4-nitrobenzeneacetic acid; With thionyl chloride; at 20 ℃;

With hydrazine hydrate; In ethanol; water; at 80 ℃; for 0.75h;

DOI:10.1039/b909612d

Reference yield: 88.0%

ETHYL 4-NITROPHENYLACETATE (5445-26-1) → 4-nitrophenylacetic acid hydrazide (6144-81-6)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.13005/ojc/330250

Reference yield:

4-nitrophenylacetyl chloride (50434-36-1) → 4-nitrophenylacetic acid hydrazide (6144-81-6)

Guidance literature:

With hydrazine; In dichloromethane; at 20 ℃; for 18h;

upstream raw materials:

methyl (4-nitrophenyl)acetate

4-nitrophenylacetyl chloride

ethanol

4-nitrobenzeneacetic acid

Downstream raw materials:

(4-nitro-phenyl)-acetic acid-(1-methyl-2-oxo-propylidene-hydrazide)

5-(4-amino-benzyl)-3H-[1,3,4]oxadiazol-2-one

Refernces

• 1、 Kumar Reddy,Kathale, Niren E.. "Synthesis and anti-inflammatory activity of hydrazones bearing biphenyl moiety and vanillin based hybrids". . p. 971 - 978. Retrieved 2017/05/29.
• 2、 Elsinghorst, Paul W.,Haertig, Wolfgang,Goldhammer, Simone,Grosche, Jens,Guetschow, Michael. "A Gorge-spanning, High-affinity cholinesterase inhibitor to explore β-amyloid plaques". supporting information; experimental part. p. 3940 - 3946. Retrieved 2009/12/05.