5445-26-1

Basic information

• Product Name: Ethyl 4-nitrophenylacetate
• Synonyms: ETHYL 4-NITROPHENYLACETATE;ETHYL P-NITROPHENYLACETATE;4-NITROPHENYLACETIC ACID ETHYL ESTER;ALPHA-ETHYL-P-NITRO PHENYL ACETIC ACID;P-NITROPHENYLACETIC ACID ETHYL ESTER;4-nitro-benzeneaceticaciethylester;Acetic acid, (p-nitrophenyl)-, ethyl ester;Acetic acid, 2-(4-nitrophenyl)-, ethyl ester
• CAS NO: 5445-26-1
• Molecular Formula: C₁₀H₁₁NO₄
• Molecular Weight: 209.2
• EINECS: 226-646-5
• Product Categories: Acids and Derivatives;Aromatic Esters;Aromatics;Miscellaneous Reagents
• Mol File: 5445-26-1.mol
• Article Data: 40

Chemical Properties

• Melting Point: 61-65 °C
• Boiling Point: 196 °C / 20mmHg
• Flash Point: 144.11 °C
• Appearance: light yellow crystalline powder
• Density: 1.2944 (rough estimate)
• Vapor Pressure: 0.000283mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, DMSO
• BRN: 2053241
• CAS DataBase Reference: Ethyl 4-nitrophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-nitrophenylacetate(5445-26-1)
• EPA Substance Registry System: Ethyl 4-nitrophenylacetate(5445-26-1)

Safety Data

• Safety Statements: 24/25
• TSCA: T
• Hazardous Substances Data: 5445-26-1(Hazardous Substances Data)

Usage

Description

Ethyl 4-nitrophenylacetate, with the CAS number 5445-26-1, is a light yellow crystalline powder that serves as a valuable compound in the realm of organic synthesis. Its unique chemical structure allows it to be utilized in various chemical reactions and processes, making it a versatile component in the field of chemistry.

Uses

Used in Organic Synthesis:
Ethyl 4-nitrophenylacetate is used as a synthetic intermediate for the production of various organic compounds. Its chemical properties enable it to participate in a range of reactions, such as esterification, hydrolysis, and substitution, which are crucial for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Ethyl 4-nitrophenylacetate is used as a key building block for the development of new drugs. Its reactivity and structural diversity make it an ideal candidate for the synthesis of novel drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
Ethyl 4-nitrophenylacetate is also employed in the agrochemical industry for the synthesis of various pesticides and other crop protection agents. Its ability to undergo multiple chemical transformations allows for the creation of a wide range of active ingredients that can help improve crop yield and protect against pests and diseases.
Used in Dye and Pigment Industry:
In the dye and pigment industry, Ethyl 4-nitrophenylacetate is utilized as a starting material for the synthesis of various organic dyes and pigments. Its light yellow crystalline form and chemical properties make it suitable for the production of colorants used in the textile, plastics, and printing industries.
Used in Research and Development:
Ethyl 4-nitrophenylacetate is also used in research and development laboratories for the study of various chemical reactions and processes. Its unique properties and reactivity make it an essential tool for chemists working on the development of new synthetic methods and the exploration of novel chemical compounds.

InChI:InChI=1/C10H11NO4/c1-2-15-10(12)7-8-3-5-9(6-4-8)11(13)14/h3-6H,2,7H2,1H3

Upstream product

• 64-17-5 ethanol 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 100-25-4 para-dinitrobenzene 
• 141-78-6 ethyl acetate 
• 681-94-7 ethyl 2-(tributylstannyl)acetate 
• 586-78-7 para-nitrophenyl bromide 
• 7697-37-2 nitric acid 
• 101-97-3 Ethyl 2-phenylethanoate 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 71-43-2 benzene 
• 105-53-3 diethyl malonate 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 107-13-1 acrylonitrile 

Downstream Products

• 129667-42-1 10-(4-nitrophenyl)-2,3,6,7-tetrahydro-11-oxo-1H,5H,11H-benzopyrano<6,7,8-i,j>quinolizine 
• 119882-20-1 4-<α-(3-Methyl-benzothiazolin-2-yliden)-α-ethoxycarbonyl>-nitrobenzen 
• 59235-35-7 4-ethoxycarbonylmethylaniline hydrochloride 
• 62-23-7 4-nitro-benzoic acid 
• 159977-15-8 ethyl 2-(4-nitrophenyl)-5-phenylpentanoate 
• 159977-14-7 ethyl 2-(4-nitrophenyl)-10-phenyldecanoate 
• 161691-88-9 ethyl [2-(4-nitrophenyl)-8-phenylthio]octanoate 
• 161691-89-0 ethyl [2-(4-nitrophenyl)-8-phenylthio]decanoate 
• 64-17-5 ethanol 
• 104-03-0 4-nitrobenzeneacetic acid 
• 3900-83-2 ethyl α-diazo-4-nitrophenylacetate 

Relevant articles and documents

Immunomodulator

The invention provides an immunomodulator, and belongs to the field of medical chemistry. The immunomodulator is a compound represented by formula I, or a stereoisomer, or a salt, or a solvate, or a prodrug, or a metabolite thereof. The compound disclosed by the invention shows good IL-17A inhibitory activity, can be used for preparing an IL-17A inhibitor, is used for treating diseases with abnormal IL-17A activity, and the invention provides a new medicinal possibility for clinically treating diseases related to abnormal IL-17A activity.

Immunomodulator

The invention discloses an immunomodulator, and particularly relates to a compound for inhibiting IL-17A and application of the compound serving as the immunomodulator in preparation of drugs. The invention discloses application of a compound shown in a formula I or a stereoisomer thereof in preparation of medicines for inhibiting IL-17A, and provides a new choice for clinically screening and/or preparing medicines for treating diseases related to IL-17A activity.

FUNCTIONALISED AMINE DERIVATIVES AS IL-17 MODULATORS

A series of functionalised amine derivatives of formula (I) as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.