2-BROMO-4,5-DIMETHOXYBENZYL ALCOHOL

Base Information

• Chemical Name: 2-BROMO-4,5-DIMETHOXYBENZYL ALCOHOL
• CAS No.: 54370-00-2
• Molecular Formula: C9H11 Br O3
• Molecular Weight: 247.089
• Hs Code.: 2909499000
• Mol file: 54370-00-2.mol

Synonyms:Veratryl alcohol, 6-bromo- (6CI,7CI);(2-Bromo-4,5-dimethoxyphenyl)methanol; 2-Bromo-4,5-dimethoxybenzyl alcohol

Chemical Property of 2-BROMO-4,5-DIMETHOXYBENZYL ALCOHOL

Chemical Property:

• Vapor Pressure: 8.63E-05mmHg at 25°C
• Melting Point: 95-100 °C
• Boiling Point: 326.7°C at 760 mmHg
• PKA: 13.77±0.10(Predicted)
• Flash Point: 151.4°C
• PSA: 38.69000
• Density: 1.475g/cm³
• LogP: 1.95860
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-4,5-dimethoxybenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-4,5-dimethoxybenzyl Alcohol is an intermediate compound used for the synthetic preparation of pharmaceutical goods. 2-Bromo-4,5-dimethoxybenzyl Alcohol have been used in the synthesis of roten oids.

Technology Process of 2-BROMO-4,5-DIMETHOXYBENZYL ALCOHOL

There total 7 articles about 2-BROMO-4,5-DIMETHOXYBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3,4-dimethoxyphenyl)methanol (93-03-8) → 2-bromo-4,5-dimethoxybenzyl alcohol (54370-00-2)

Guidance literature:

With lithium bromide monohydrate; [bis(acetoxy)iodo]benzene; In 2,2,2-trifluoroethanol; at 20 ℃; for 0.166667h; regiospecific reaction;

DOI:10.1055/s-0037-1610980

Reference yield: 100.0%

2-bromo-4,5-dimethoxybenzaldehyde (5392-10-9) → 2-bromo-4,5-dimethoxybenzyl alcohol (54370-00-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃;

Reference yield: 90.0%

2-bromo-4,5-dimethoxybenzoic acid (6286-46-0) → 2-bromo-4,5-dimethoxybenzyl alcohol (54370-00-2)

Guidance literature:

2-bromo-4,5-dimethoxybenzoic acid; With borane-THF; at 20 ℃; for 3.5h;

With hydrogenchloride; In water; at 0 ℃;

DOI:10.1016/j.ejmech.2015.03.005

upstream raw materials:

2-bromo-4,5-dimethoxybenzaldehyde

methanol

(3,4-dimethoxyphenyl)methanol

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

C₄₄H₄₈Br₂O₁₀

5,6-dimethoxy-3H-benz<2,1>oxathiole S-oxide

(2-bromo-4,5-dimethoxyphenyl)methanethiol

2,3,13,14-Tetrakis-(2-bromo-4,5-dimethoxy-benzyl)-6,7,9,10,17,18,20,21-octahydro-5,8,11,16,19,22-hexaoxa-dibenzo[a,j]cyclooctadecene

Refernces

• 1、 Satpathi, Bishnupada,Dutta, Lona,Ramasastry. "Metal- and Hydride-Free Pentannulative Reductive Aldol Reaction". supporting information. p. 170 - 174. Retrieved 2019/01/04.
• 2、 Shibata, Ayako,Kitamoto, Sara,Fujimura, Kazuma,Hirose, Yuuka,Hamamoto, Hiromi,Nakamura, Akira,Miki, Yasuyoshi,Maegawa, Tomohiro. "Dehydroxymethyl Bromination of Alkoxybenzyl Alcohols by Using a Hypervalent Iodine Reagent and Lithium Bromide". supporting information. p. 2275 - 2278. Retrieved 2018/10/20.