2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE

Base Information

• Chemical Name: 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE
• CAS No.: 42487-72-9
• Molecular Formula: C9H15 N3 O
• Molecular Weight: 181.238
• Hs Code.: 2933599090
• Mol file: 42487-72-9.mol

Synonyms:4(1H)-Pyrimidinone,2-(diethylamino)-6-methyl- (9CI);2-(Diethylamino)-4-hydroxy-6-methylpyrimidine; 2-(Diethylamino)-6-methyl-4-hydroxypyrimidine;2-Diethylamino-6-methyl pyrimidin-4-ol

Chemical Property of 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.00887mmHg at 25°C
• Melting Point: 133-134 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 266°Cat760mmHg
• PKA: 10.28±0.50(Predicted)
• Flash Point: 114.7°C
• PSA: 49.25000
• Density: 1.1g/cm³
• LogP: 1.33680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.9% ^*data from raw suppliers

2-DIethylamino-6-hydroxy-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-DIethylamino-6-hydroxy-4-methylpyrimidine is used in the synthesis of heterocyclic compounds with two heteroatoms, displaying pharmacophoric properties. Also used in the synthesis of dual imhibitors for the HIV-1 caspid and human cyclophilin A enzymes which both play essential roles in HIV-1 assembly and replication.

Technology Process of 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE

There total 10 articles about 2-DIETHYLAMINO-6-HYDROXY-4-METHYLPYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.2%

ethyl acetoacetate (141-97-9) + N,N-Diethylguanidine sulphate → 2-diethylamino-4-hydroxy-6-methyl-pyrimidine (42487-72-9)

Guidance literature:

N,N-Diethylguanidine sulphate; With sodium hydroxide; In methanol; at 35 ℃; for 1h;

ethyl acetoacetate; In methanol; at 105 ℃; Inert atmosphere; Dean-Stark;

Reference yield: 86.1%

1,1-diethylguanidine (18240-93-2) + ethyl acetoacetate (141-97-9) → 2-diethylamino-4-hydroxy-6-methyl-pyrimidine (42487-72-9)

Guidance literature:

at 130 ℃; for 0.00555556h;

Reference yield: 80.0%

2-N,N-diethylamino-4-methoxy-6-methylpyrimidine (111697-06-4) → 2-diethylamino-4-hydroxy-6-methyl-pyrimidine (42487-72-9)

Guidance literature:

With hydrogenchloride; Heating; overnight;

DOI:10.1002/jhet.5570240137

upstream raw materials:

2-N,N-diethylamino-4-methoxy-6-methylpyrimidine

2-chloro-4-methoxy-6-methyl-pyrimidine

citric acid monohydrate

4-methyl-2-pentanone

Downstream raw materials:

Pirimiphos-methyl

Refernces

• 1、 -. "Continuous synthesis method of hydroxypyrimidine compound". Paragraph 0012; 0028-0029. . Retrieved 2020/07/28.
• 2、 -. "Acetyl hydrazone derivative containing pyrimidine structure and preparation method and application thereof". Paragraph 0013; 0023. . Retrieved 2017/07/20.