N-(2,3-dichlorophenyl)formamide

Base Information

• Chemical Name: N-(2,3-dichlorophenyl)formamide
• CAS No.: 6327-47-5
• Molecular Formula: C7H5 Cl2 N O
• Molecular Weight: 190.029
• Mol file: 6327-47-5.mol

Synonyms:Formanilide, 2',3'-dichloro- (7CI);2,3-Dichloroformanilide; NSC 50861

Chemical Property of N-(2,3-dichlorophenyl)formamide

Chemical Property:

• Vapor Pressure: 2.37E-05mmHg at 25°C
• Boiling Point: 359.5°Cat760mmHg
• Flash Point: 171.2°C
• Density: 1.46g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,3-dichlorophenyl)formamide

There total 4 articles about N-(2,3-dichlorophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

formic acid (64-18-6) + 2,3-dichloroaniline (608-27-5) → 2,3-dichloroformanilide (6327-47-5)

Guidance literature:

With sulfonic acid functionalized on biguanidine fabricated silica coated heterogeneous magnetic nanoparticles; In ethanol; at 20 ℃; for 0.166667h;

DOI:10.1039/d0ra07476d

Reference yield: 63.0%

2,3-dichloroaniline (608-27-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,3-dichloroformanilide (6327-47-5)

Guidance literature:

With hydrogenchloride; In water; at 130 ℃; for 2h; Sealed tube; Green chemistry;

DOI:10.1080/00397911.2021.1989597

Reference yield:

2,3-dichloroaniline (608-27-5) + formyl acetic anhydride (2258-42-6) → 2,3-dichloroformanilide (6327-47-5)

Guidance literature:

In diethyl ether; hexane; at 0 - 20 ℃;

DOI:10.1002/anie.201611024

upstream raw materials:

formic acid

2,3-dichloroaniline

formyl acetic anhydride

N,N-dimethyl-formamide

Downstream raw materials:

4-Amino-2,3-dichloro-benzenesulfonic acid

2,3-dichloro-4-nitrobenzenesulphonic acid

4-(5-Amino-3-methyl-1-phenyl-1H-pyrazol-4-ylazo)-2,3-dichloro-benzenesulfonic acid

2,3-Dichloro-4-(4,6-diamino-2-ethylsulfanyl-pyrimidin-5-ylazo)-benzenesulfonic acid

Refernces

• 1、 Agarwal, Alka,Awasthi, Satish K.,Yadav, Jitendra Kumar,Yadav, Priyanka. "Efficient: N -formylation of primary aromatic amines using novel solid acid magnetic nanocatalyst". . p. 41229 - 41236. Retrieved 2020/11/23.
• 2、 -. "Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents". Page column 157. . Retrieved 2010/02/05.