(1-Methylpyrrolidin-2-yl)methanamine

Base Information

• Chemical Name: (1-Methylpyrrolidin-2-yl)methanamine
• CAS No.: 26171-06-2
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 2933990090
• European Community (EC) Number: 247-496-7
• DSSTox Substance ID: DTXSID00949041
• Nikkaji Number: J308.396I
• Mol file: 26171-06-2.mol

Synonyms:26171-06-2;(1-methylpyrrolidin-2-yl)methanamine;1-Methylpyrrolidine-2-methylamine;2-pyrrolidinemethanamine, 1-methyl-;C-(1-methyl-pyrrolidin-2-yl)-methylamine;EINECS 247-496-7;MFCD09971798;1-(1-methylpyrrolidin-2-yl)methanamine;(1-METHYLPYRROLIDIN-2-YL)METHYLAMINE;1-Methyl-2-pyrrolidinemethanamine;2-Aminomethyl-1-methylpyrrolidine;1-Methylpyrrolidine-2-methanamine;1-methyl-2-aminomethyl-pyrrolidine;2-Pyrrolidinemethanamine,1-methyl-;1-(1-methyl-2-pyrrolidinyl)methanamine;SCHEMBL1621133;1-methyl-2-aminomethylpyrrolidine;DTXSID00949041;2-Aminomethyl-1-methyl-pyrrolidine;STK897784;AKOS000210759;AKOS016344181;PB21275;PB34570;rac 2-Aminomethyl-1-methyl-pyrrolidine;[(1-methylpyrrolidin-2-yl)methyl]amine;C-(1-methylpyrrolidin-2-yl)methylamine;AM100590;BS-12847;SY065143;BB 0259871;CS-0128646;FT-0648680;FT-0678401;EN300-55709;D82178;(1-Methylpyrrolidin-2-yl)methylamine, AldrichCPR;A877342;Z326202522

Chemical Property of (1-Methylpyrrolidin-2-yl)methanamine

Chemical Property:

• Vapor Pressure: 11.5mmHg at 25°C
• Refractive Index: 1.473
• Boiling Point: 126.7 °C at 760 mmHg
• PKA: 9.97±0.40(Predicted)
• Flash Point: 32.7 °C
• PSA: 29.26000
• Density: 0.917 g/cm³
• LogP: 0.67750
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 72.9

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-2-pyrrolidinemethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCCC1CN

Technology Process of (1-Methylpyrrolidin-2-yl)methanamine

There total 6 articles about (1-Methylpyrrolidin-2-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2-aminomethyl-1-methyl-1H-pyrrole (69807-81-4) → 1-methyl-2-aminomethyl-pyrrolidine (26171-06-2)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; Ambient temperature;

DOI:10.1248/cpb.38.930

Reference yield:

→ 1-methyl-2-aminomethyl-pyrrolidine (26171-06-2)

Guidance literature:

With ethanol; nickel; Hydrogenation;

DOI:10.1021/ja01519a057

Reference yield:

N-methylpyrrole aldehyde (1192-58-1) → 1-methyl-2-aminomethyl-pyrrolidine (26171-06-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 28.1 g / NH₂OH*HCl, sodium acetate / ethanol; H₂O / 1 h / Ambient temperature

2: 8.3 g / zinc powder, acetic acid / H₂O / 1 h / 0 °C

3: 42 percent / 10percent HCl, hydrogen / PtO₂ / aq. ethanol / Ambient temperature

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic acid; zinc; platinum(IV) oxide; In ethanol; water;

DOI:10.1248/cpb.38.930

upstream raw materials:

2-aminomethyl-1-methyl-1H-pyrrole

N-methylpyrrole aldehyde

1-methylpyrrol-2-carboxaldoxime

C₈H₁₄N₂O₃

Downstream raw materials:

N-(1-methyl 2-pyrrolidylmethyl) 2-methoxy 4-amino 5-methylsulphonyl benzamide

N-(1-methyl-2-pyrrolidylmethyl)-2-methoxy-4-amino-5-ethylsulphonylbenzamid

7-(N,N-dimethylsulfamoyl)-2,3-dihydro-N-[(1-methyl-2-pyrrolidinyl)methyl]-1,4-benzodioxin-5-carboxamide

2-amino-4-methoxy-pyrimidine-5-carboxylic acid 1-methyl-pyrrolidin-2-ylmethyl-amide

Refernces

• 1、 -. "Isothiazolecarboxylic acid derivatives and their use as microbicides". . . Retrieved 2008/06/13.