N1-isoamylleucinamide

Base Information

• Chemical Name: N1-isoamylleucinamide
• CAS No.: 84851-37-6
• Molecular Formula: C11H24N2O
• Molecular Weight: 200.324
• Mol file: 84851-37-6.mol

Synonyms:L-leucine isopentylamide;L-leucine isoamylamide;Leucine-Isoamylamide;leucine 3-methylbutylamide;

Chemical Property of N1-isoamylleucinamide

Chemical Property:

• PSA: 55.12000
• LogP: 2.61330

Purity/Quality:

99% ^*data from raw suppliers

S-2-Amino-4-methylpentanoic acid (3-methylbutyl)amide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N1-isoamylleucinamide

There total 17 articles about N1-isoamylleucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate (84863-67-2) → (S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride (84851-37-6,167693-86-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.75h; Ambient temperature;

DOI:10.1021/jm950445b

Reference yield: 99.6%

(S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate (84863-67-2) → N1-isoamylleucinamide (84851-37-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 2.5h; Ambient temperature;

DOI:10.1248/cpb.35.1098

Reference yield: 99.0%

1-amino-3-methylbutane (107-85-7) + N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → N1-isoamylleucinamide (84851-37-6)

Guidance literature:

1-amino-3-methylbutane; N-tert-butoxycarbonyl-L-leucine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate;

With hydrogenchloride; In ethyl acetate;

upstream raw materials:

(S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate

N-tert-butoxycarbonyl-L-leucine

Boc-Leu-O-COO-isoBu

isoamylamine hydrochloride

Downstream raw materials:

loxistatin acid

(2S,3S)-Oxirane-2,3-dicarboxylic acid 2-(benzyloxy-amide) 3-{[(S)-3-methyl-1-(3-methyl-butylcarbamoyl)-butyl]-amide}

aloxistatin

(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium

Refernces

• 1、 Nasief, Nader N.,Hangauer, David. "Additivity or cooperativity: Which model can predict the influence of simultaneous incorporation of two or more functionalities in a ligand molecule?". . p. 897 - 915. Retrieved 2015/05/27.
• 2、 Yu, Ying-Ying,Sun, Wei,Dong, Lei,Liu, Hai-Dong,Jiang, Dan,Xiao, Jun-Hai,Yang, Xiao-Hong,Li, Song. "Design, synthesis, and screen of cathepsin K inhibitors". . p. 715 - 718. Retrieved 2013/07/26.