1-benzyl-4-phenylpiperidine

Base Information

• Chemical Name: 1-benzyl-4-phenylpiperidine
• CAS No.: 19015-37-3
• Molecular Formula: C18H21N
• Molecular Weight: 251.371
• Mol file: 19015-37-3.mol

Synonyms:

Chemical Property of 1-benzyl-4-phenylpiperidine

Chemical Property:

• Vapor Pressure: 1.83E-05mmHg at 25°C
• Boiling Point: 363.3°Cat760mmHg
• Flash Point: 156.4°C
• Density: 1.047g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl-4-phenylpiperidine

There total 25 articles about 1-benzyl-4-phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

4-phenylpiperidine (771-99-3) + benzyl alcohol (100-51-6,185532-71-2) → 1-(phenylmethyl)-4-phenylpiperidine (19015-37-3)

Guidance literature:

With trimethylamine-N-oxide; tricarbonyl(η⁴-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 16h; Sealed tube;

DOI:10.1021/acs.joc.7b01990

Reference yield: 83.0%

3-phenylpentane-1,5-diol (829-27-6) + benzylamine (100-46-9) → 1-(phenylmethyl)-4-phenylpiperidine (19015-37-3)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium hydrogencarbonate; In toluene; at 110 ℃; for 16h; Microwave irradiation; Inert atmosphere; Sealed tube;

DOI:10.1039/d0cc00903b

Reference yield: 75.0%

1-Benzyl-4-phenyl-pyridinium; bromide (89290-93-7) → 1-(phenylmethyl)-4-phenylpiperidine (19015-37-3)

Guidance literature:

With formic acid; C₃₂H₃₁BrClIrN₂O₂; triethylamine; In isopropyl alcohol; at -10 ℃; for 16h; Schlenk technique;

DOI:10.1039/d0ob02049d

upstream raw materials:

1-(phenylmethyl)-4-phenylpiperidin-2,6-dione

3-phenyl-glutaric acid bis-benzylamide

1-benzyl-4-phenyl-piperidine-4-carbonitrile; hydrochloride

1,4-dioxane

Downstream raw materials:

phenyl(4-phenylpiperidin-1-yl)methanone

1-benzyl-5,6-dihydro-4-phenylpyridin-2(1H)-one

4-phenylpiperidine

4-Phenyl-piperidine-1-carboxylic acid 2-trimethylsilanyl-ethyl ester

Refernces

• 1、 Lyu, Hairong,Kevlishvili, Ilia,Yu, Xuan,Liu, Peng,Dong, Guangbin. "Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis". . . Retrieved 2021/04/30.
• 2、 Armstrong, Roly J.,Chamberlain, Anna E. R.,Donohoe, Timothy J.,Paterson, Kieran J.,Twin, Heather C.. "A hydrogen borrowing annulation strategy for the stereocontrolled synthesis of saturated aza-heterocycles". supporting information. p. 3563 - 3566. Retrieved 2020/04/03.