3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Base Information

• Chemical Name: 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid
• CAS No.: 154775-43-6
• Molecular Formula: C13H23NO4
• Molecular Weight: 257.33
• Hs Code.: 29333990
• European Community (EC) Number: 801-586-8,672-412-4
• Nikkaji Number: J1.342.754B
• Mol file: 154775-43-6.mol

Synonyms:154775-43-6;3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid;1-Boc-piperidin-4-ylpropionic acid;154375-43-6;N-Boc-4-piperidinepropionic acid;1-boc-piperidine-4-ylpropionic acid;3-(1-boc-piperidine-4-yl)-propionic acid;3-{1-[(tert-butoxy)carbonyl]piperidin-4-yl}propanoic acid;MFCD01861212;3-[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]propanoic acid;3-(1-boc-piperidin-4-yl)-propionic acid;1-boc-piperidine-4-propanoic acid;4-(2-carboxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester;4-PIPERIDINEPROPANOIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-;3-[1-(tert-butoxycarbonyl)piperidin-4-yl]propanoic acid;1-boc-4-piperidinepropionic acid;3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propionic acid;3-[1-(tert-Butoxycarbonyl)piperidin-4-yl]propionic acid;3-(1-TERT-BUTOXYCARBONYL-4-PIPERIDYL)PROPANOIC ACID;1-Boc-piperidin-4-ylpropionicacid;3-(1-Boc-4-piperidyl)propionic Acid;SCHEMBL381974;1-boc-4-piperidinepropanoic acid;n-boc-piperidinyl-4-propionic acid;4-(2-Carboxyethyl)piperidine-1-carboxylic acid tert-butyl ester;1-N-Boc-4-Piperidinepropanoic Acid;1-Boc-piperidine-4-ylpropanoic acid;1-Boc-piperidine-4-ylpropionic?acid;AKOS011497385;AC-6548;AC-9454;CS-W001452;GS-3857;3-(1-BOC-piperidin-4-yl)propanoic acid;AM100292;SY034275;3-(N-Boc-piperidine-4-yl)-propionic acid;N-BOC-4- PIPERIDINE PROPIONIC ACID;FT-0600978;FT-0651912;EN300-61317;A26711;1-Boc-piperidin-4-ylpropionic acid, AldrichCPR;1-(tert-Butoxycarbonyl)-4-piperidinepropionic acid;3-(1-t-butoxycarbonylpiperidin-4-yl)propionic acid;3-(1-tert-butoxycarbonyl-4-piperidyl)propionic acid;J-504380;W-205764;3-(1-t-butyloxycarbonylpiperidin-4-yl)propionic acid;3-(1-tert-butoxycarbonylpiperidin-4-yl)propionic acid;3-[1-(t-butyloxycarbonyl)piperidin4-yl]propanoic acid;3-[1-(tert-butoxycarbonyl)-4-piperidinyl]propanoic acid;Z963573930;(Z)-4,4,5,5,6,6,6-Heptafluoro-3-phenylhex-2-enoicacid;Boc-piperidine-4-propanoic acid

Chemical Property of 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

Chemical Property:

• Vapor Pressure: 4.83E-07mmHg at 25°C
• Boiling Point: 386.4 °C at 760 mmHg
• PKA: 4.73±0.10(Predicted)
• Flash Point: 187.5 °C
• PSA: 66.84000
• Density: 1.102 g/cm³
• LogP: 2.43620
• Storage Temp.: 2-8°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 257.16270821
• Heavy Atom Count: 18
• Complexity: 301

Purity/Quality:

99% ^*data from raw suppliers

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1CCC(CC1)CCC(=O)O

Technology Process of 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid

There total 22 articles about 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate (301232-45-1) → 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid (154775-43-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.3987/com-01-9213

Reference yield: 91.0%

tert-butyl 4-(3-methoxy-3-oxopropyl)piperidine-1-carboxylate (162504-75-8) → 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid (154775-43-6)

Guidance literature:

With sodium hydroxide; In methanol; for 0.5h; Ambient temperature;

DOI:10.1021/jm9801096

Reference yield: 90.0%

3-(4-piperidyl)propionic acid (1822-32-8) + di-tert-butyl dicarbonate (24424-99-5) → 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid (154775-43-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(99)00179-1

upstream raw materials:

3-(4-piperidyl)propionic acid

di-tert-butyl dicarbonate

tert-butyl 4-(3-methoxy-3-oxopropyl)piperidine-1-carboxylate

tert-butyl 4-(3-ethoxy-3-oxopropyl)-1-piperidinecarboxylate

Downstream raw materials:

tert-butyl 4-{3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}piperidine-1-carboxylate

Refernces

• 1、 Amans, Dominique,Bellosta, Véronique,Dacquet, Catherine,Ktorza, Alain,Hennuyer, Nathalie,Staels, Bart,Caignard, Daniel-Henri,Cossy, Janine. "Synthesis and evaluation of new polyenic compounds as potential PPARs modulators". experimental part. p. 6169 - 6185. Retrieved 2012/09/05.
• 2、 Yamanaka, Toshio,Ohkubo, Mitsuru,Kuroda, Satoru,Nakamura, Hideko,Takahashi, Fumie,Aoki, Toshiaki,Mihara, Kayoko,Seki, Jiro,Kato, Masayuki. "Design, synthesis, and structure-activity relationships of potent GPIIb/IIIa antagonists: Discovery of FK419". . p. 4343 - 4352. Retrieved 2007/10/03.