301232-45-1

Basic information

• Product Name: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate
• Synonyms: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate;4-(2-Ethoxycarbonylethyl)piperidine-1-carboxylic acid tert-butyl ester;4-Piperidinepropanoic acid, 1-[(1,1-diMethylethoxy)carbonyl]-, ethylester;Ethyl 3-(N-BOC-piperidin-4-yl)propioate;1-Boc-4-piperidinepropanoic acid ethyl ester
• CAS NO: 301232-45-1
• Molecular Formula: C₁₅H₂₇NO₄
• Molecular Weight: 285.37918
• Mol File: 301232-45-1.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.036
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate(301232-45-1)
• EPA Substance Registry System: tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate(301232-45-1)

Safety Data

• Hazardous Substances Data: 301232-45-1(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate is a chemical compound. As the name suggests, it includes elements such as tert-butyl and ethoxy groups, along with a piperidine ring and a carboxylate ester functional group. tert-butyl 4-(3-ethoxy-3-oxopropyl)piperidine-1-carboxylate falls under the category of organic compounds, specifically, tertiary butyl groups are a subset of alkyl compounds. Its exact properties such as reactivity, stability, toxicology or applications may vary based on its specific interactions with other compounds, and are not generally described unless in a specific context or study.

Upstream product

• 198895-61-3 t-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-tetrahydropyridine-1(2H)-carboxylate 
• 162504-86-1 t-butyl 4-(3-ethoxy-3-oxoprop-1-enyl)-tetrahydropyridine-1(2H)-carboxylate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 123293-78-7 ethyl 3-(4-pyridinyl)-(2E)-propenoate 
• 872-85-5 pyridine-4-carbaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 473987-06-3 ethyl 3-(4-piperidinyl)propanoate hydrochloride 
• 71879-55-5 ethyl 3-(piperid-4-yl)propionate 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 51144-70-8 ethyl 3-(1-benzoylpiperidin-4-yl)propanoate 
• 71879-55-5 ethyl 3-(piperid-4-yl)propionate 
• 1305197-32-3 N-hydroxy-3-(1-phenylacetyl-piperidin-4-yl)-propionamide 
• 1305197-31-2 3-(1-benzoyl-piperidin-4-yl)-N-hydroxy-propionamide 
• 1305197-30-1 3-(1-benzenesulfonyl-piperidin-4-yl)-N-hydroxy-propionamide 
• 1305197-29-8 N-hydroxy-3-(1-phenylmethanesulfonyl-piperidin-4-yl)-propionamide 
• 1822-32-8 3-(4-piperidyl)propionic acid 
• 264235-84-9 tert-butyl 4-[3-((3R)-3-{[((2R)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 223697-44-7 tert-butyl 4-[3-((3R)-3-{[((2S)-2-{[(benzyloxy)carbonyl]amino}-3-methoxy-3-oxopropyl)amino]carbonyl}-1-piperidinyl)-3-oxopropyl]-1-piperidinecarboxylate 
• 154775-43-6 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid 

Relevant articles and documents

Electrochemical Tandem Olefination and Hydrogenation Reaction with Ammonia

An electrochemical Horner-Wadsworth-Emmons/hydrogenation tandem reaction was achieved using ammonia as electron and proton donors. The reaction could give two-carbon-elongated ester and nitrile from aldehyde or ketones directly. This reaction could proceed with a catalytic amount of base or even without a base. The ammonia provides both the electron and proton for this tandem reaction and enables the catalyst-free hydrogenation of an α,β-unsaturated HWE intermediate. More than 40 examples were reported, and functional groups, including heterocycles and hydroxyl, were tolerated.

One-Pot, Tandem Wittig Hydrogenation: Formal C(sp3)-C(sp3) Bond Formation with Extensive Scope

A one-pot, tandem Wittig hydrogenation of aldehydes with stabilized ylides is reported, representing a formal C(sp3)-C(sp3) bond construction. The tandem reaction operates under mild conditions, is high yielding, and is broad in scope. Chemoselectivity for olefin reduction is observed, and the methodology is demonstrated in the synthesis of lapatinib analogues and a formal synthesis of (±)-cuspareine. Early insights suggest that the chemoselectivity observed in the reduction step is due to partial poisoning of the catalyst, after step one, thus adding to the power of the one-pot procedure.

Design, synthesis, and structure-activity relationships of potent GPIIb/IIIa antagonists: Discovery of FK419

The discovery of the non-peptide antiplatelet injectable agent FK419 is reported. Based on the β-turn structure of RGD peptide sequences in the α chain of fibrinogen, which binds the glycoprotein IIb/IIIa (GPIIb/IIIa) on the surface of platelets to induce