867-13-0Relevant articles and documents
Reimann,Voss
, p. 2,8 (1977)
One-pot synthesis and antimicrobial of novel 6-ethoxy-6-oxido-3-oxo(thioxo) (imino)-5-substituted-2,7-dihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes
Ali, Tarik E.,Assiri, Mohammed A.
, p. 965 - 969 (2021)
A series of novel 6-ethoxy-6-oxido-3-oxo(thioxo)(imino)-5-substituted-2,7-dihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes 2a-f was synthesized and characterized by IR and NMR (1H, 13C, and 31P) spectroscopic analysis. The methodology developed was one-pot three-component reaction of ethyl bromoacetate, triethyl phosphite and carbo(thio)(amino)hydrazides. The synthesized compounds were screened for their antimicrobial activities. 6-Ethoxy-6-oxido-3-oxo(thioxo)-5-phenyl-2,5,7-trihydro-1,2,4-triazolo[3,4-e][1,2,3]diazaphospholes (2c,d) exhibited significantly higher antimicrobial effects against the tested bacterial and fungal strains compared to other compounds and standard drug.
Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines
Ali,Assiri,Yahia,Zahran,Meselhy,Hussien
, p. 79 - 84 (2021/03/04)
Abstract: The reactions of6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilicreagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, andethyl chloroacetate, were studied. These one-pot three-component reactionsregioselectively afforded four new11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in69–73% yields.
Synthesis method of triethyl phosphonoacetate
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Paragraph 0017; 0019; 0021; 0024; 0026; 0029; 0031, (2017/08/27)
Relating to the field of organic compound synthesis, the invention provides a synthesis method of triethyl phosphonoacetate. Triethyl phosphate and ethyl chloroacetate are taken as the raw materials to carry out Michael arbuzov rearrangement reaction, thus obtaining triethyl phosphonoacetate. The chemical reaction formulas of the synthesis method are: CH2ClCOOH+C2H5OH to C4H7ClO2+H2O, C4H7ClO2+C6H15O3P to C8H17O5P+C2H5Cl. The method provided by the invention solves the problems of high energy consumption, high cost and low product purity in the traditional process, also solves the problem of byproduct application in a synthetic environment, and achieves good economic and social benefits.