Manidipine

Base Information Edit

Chemical Name:Manidipine
CAS No.:89226-50-6
Deprecated CAS:120092-68-4
Molecular Formula:C35H38N4O6
Molecular Weight:610.71
Hs Code.:
European Community (EC) Number:855-394-4
UNII:6O4754US88
DSSTox Substance ID:DTXSID2043745
Wikipedia:Manidipine
Wikidata:Q921133
NCI Thesaurus Code:C81682
Pharos Ligand ID:WWTKP1W9G7R7
Metabolomics Workbench ID:152270
ChEMBL ID:CHEMBL1085699,CHEMBL312176
Mol file:89226-50-6.mol

Synonyms:(+)-manidipine;(+)-manidipine dihydrochloride;(-)-manidipine;(-)-manidipine dihydrochloride;(R)-(-)-manidipine;(R)-(-)-manidipine dihydrochloride;(R)-manidipine;(R)-manidipine dihydrochloride;(S)-(+)-manidipine;(S)-(+)-manidipine dihydrochloride;(S)-manidipine;(S)-manidipine dihydrochloride;2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;CV 4093;CV-4093;manidipine;manidipine dihydrochloride;manidipine hydrochloride;manidipine, (+-)-isomer

Suppliers and Price of Manidipine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Manidipine
1g
$ 725.00

Medical Isotopes, Inc.
Manidipine
100 mg
$ 425.00

Matrix Scientific
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 95+%
1g
$ 700.00

Matrix Scientific
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 95+%
250mg
$ 324.00

Matrix Scientific
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 95+%
5g
$ 1750.00

DC Chemicals
Manidipine(CV-4093) >98%
1 g
$ 1000.00

DC Chemicals
Manidipine(CV-4093) >98%
100 mg
$ 250.00

Crysdot
Manidipine 98+%
50mg
$ 53.00

Crysdot
Manidipine 98+%
100mg
$ 80.00

Cayman Chemical
Manidipine ≥98%
10mg
$ 97.00

Total 43 raw suppliers

Chemical Property of Manidipine Edit

Chemical Property:

Vapor Pressure:1.07E-20mmHg at 25°C
Melting Point:125-128°C
Refractive Index:1.6
Boiling Point:722 °C at 760 mmHg
PKA:6.12±0.10(Predicted)
Flash Point:390.4 °C
PSA：116.93000
Density:1.232 g/cm³
LogP:5.68080
Storage Temp.:-20°C Freezer
XLogP3:5.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:610.27913494
Heavy Atom Count:45
Complexity:1090

Purity/Quality:

99% ^*data from raw suppliers

Manidipine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC
Recent ClinicalTrials:Manidipine Versus Amlodipine in Patients With Hypertension
Recent EU Clinical Trials:DOUBLE BLIND, RANDOMISED, PARALLEL GROUP, MULTICENTRE STUDY TO EVALUATE THE EFFECTS OF MANIDIPINE 20 MG VS AMLODIPINE 10 MG AND THE COMBINATION OF MANIDIPINE 10 MG PLUS DELAPRIL 30 MG VS AMLODIPINE 5 MG PLUS DELAPRIL 30 MG ON INTRAGLOMERULAR PRESSURE IN HYPERTENSIVE PATIENTS.
Recent NIPH Clinical Trials:The influence of azelnidipine on plasma renin activity and plasma aldosterone concentration in hypertensive patients.
Description Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.
Uses Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It A dihydropyridine calcium channel blocker. Antihypertensive.

Technology Process of Manidipine

There total 9 articles about Manidipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%