Manidipine dihydrochloride

Base Information Edit

Chemical Name:Manidipine dihydrochloride
CAS No.:89226-75-5
Deprecated CAS:126229-12-7
Molecular Formula:C₃₅H₃₈N₄O₆*2ClH
Molecular Weight:683.632
Hs Code.:2942000000
European Community (EC) Number:680-304-3
UNII:ZL507UZ6QL
DSSTox Substance ID:DTXSID9020796
Wikidata:Q27295683
ChEMBL ID:CHEMBL2362693
Mol file:89226-75-5.mol

Synonyms:(+)-manidipine;(+)-manidipine dihydrochloride;(-)-manidipine;(-)-manidipine dihydrochloride;(R)-(-)-manidipine;(R)-(-)-manidipine dihydrochloride;(R)-manidipine;(R)-manidipine dihydrochloride;(S)-(+)-manidipine;(S)-(+)-manidipine dihydrochloride;(S)-manidipine;(S)-manidipine dihydrochloride;2-(4-diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate;CV 4093;CV-4093;manidipine;manidipine dihydrochloride;manidipine hydrochloride;manidipine, (+-)-isomer

Suppliers and Price of Manidipine dihydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Manidipine dihydrochloride
250mg
$ 235.00

TCI Chemical
Manidipine Dihydrochloride >98.0%(HPLC)(T)
1g
$ 168.00

TCI Chemical
Manidipine Dihydrochloride >98.0%(HPLC)(T)
5g
$ 577.00

Sigma-Aldrich
Manidipine hydrochloride ≥98% (HPLC)
25mg
$ 301.00

Sigma-Aldrich
Manidipine hydrochloride ≥98% (HPLC)
5mg
$ 74.40

Matrix Scientific
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride 95+%
1g
$ 82.00

Matrix Scientific
3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride 95+%
5g
$ 251.00

DC Chemicals
ManidipineDihydrochlorid >98%
1 g
$ 300.00

Crysdot
Manidipine dihydrochloride 98+%
100mg
$ 122.00

ChemScene
Manidipine dihydrochloride 98.87%
50mg
$ 66.00

Total 166 raw suppliers

Chemical Property of Manidipine dihydrochloride Edit

Chemical Property:

Vapor Pressure:1.07E-20mmHg at 25°C
Melting Point:157-163°; mp 174-180°; mp 167-170°
Boiling Point:722 °C at 760 mmHg
Flash Point:390.4 °C
PSA：116.93000
LogP:6.48280
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:Soluble in DMSO (>25 mg/ml)
Water Solubility.:Soluble in DMSO. Slightly soluble in water and ethanol /n
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:11
Exact Mass:682.2324904
Heavy Atom Count:47
Complexity:1090

Purity/Quality:

99% ^*data from raw suppliers

Manidipine dihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(C(=C(N1)C)C(=O)OCCN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-])C(=O)OC.Cl.Cl
Recent EU Clinical Trials:DOUBLE BLIND, RANDOMISED, PARALLEL GROUP, MULTICENTRE STUDY TO EVALUATE THE EFFECTS OF MANIDIPINE 20 MG VS AMLODIPINE 10 MG AND THE COMBINATION OF MANIDIPINE 10 MG PLUS DELAPRIL 30 MG VS AMLODIPINE 5 MG PLUS DELAPRIL 30 MG ON INTRAGLOMERULAR PRESSURE IN HYPERTENSIVE PATIENTS.
Description Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4
Uses aldosterone antagonist Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

Technology Process of Manidipine dihydrochloride

There total 16 articles about Manidipine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.8%