4-FLUORO-3'-TRIFLUOROMETHYLBIPHENYL

Base Information

• Chemical Name: 4-FLUORO-3'-TRIFLUOROMETHYLBIPHENYL
• CAS No.: 86967-67-1
• Molecular Formula: C13H8F4
• Molecular Weight: 240.19600
• Hs Code.: 2903999090
• Mol file: 86967-67-1.mol

Synonyms:4-Fluor-3'-trifluormethylbiphenyl;4-Fluor-3-chlor-formanilid;

Chemical Property of 4-FLUORO-3'-TRIFLUOROMETHYLBIPHENYL

Chemical Property:

• PSA: 0.00000
• LogP: 4.51150

Purity/Quality:

95% ^*data from raw suppliers

4'-FLUORO-3-(TRIFLUOROMETHYL)BIPHENYL ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-3'-TRIFLUOROMETHYLBIPHENYL

There total 2 articles about 4-FLUORO-3'-TRIFLUOROMETHYLBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

→ 4-Fluor-3'-trifluormethylbiphenyl (86967-67-1)

Guidance literature:

Reference yield:

(meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) + 1-Bromo-4-fluorobenzene (460-00-4) → 4-Fluor-3'-trifluormethylbiphenyl (86967-67-1)

Guidance literature:

With tetra-butylammonium acetate; Pd EnCat-30^TM; In acetonitrile; at 140 ℃; for 0.25h; microwave irradiation;

DOI:10.1002/chem.200501400

Reference yield: 85.0%

4-Fluor-3'-trifluormethylbiphenyl (86967-67-1) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1,3,2-dioxaborolane

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; In toluene; at 80 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b02228

upstream raw materials:

(meta-(trifluoromethyl)phenyl)boronic acid

1-Bromo-4-fluorobenzene

Refernces

• 1、 Baxendale, Ian R.,Griffiths-Jones, Charlotte M.,Ley, Steven V.,Tranmer, Geoffrey K.. "Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations". . p. 4407 - 4416. Retrieved 2008/02/07.