[1]Benzothieno[3,2-b]quinoline

Base Information

• Chemical Name: [1]Benzothieno[3,2-b]quinoline
• CAS No.: 243-68-5
• Molecular Formula: C₁₅H₉NS
• Molecular Weight: 235.309
• European Community (EC) Number: 668-423-9
• DSSTox Substance ID: DTXSID70356667
• Nikkaji Number: J1.374.666D
• Wikidata: Q82136172
• Mol file: 243-68-5.mol

Synonyms:[1]benzothieno[3,2-b]quinoline;243-68-5;Benzo[4,5]thieno[3,2-b]quinoline;SCHEMBL11709984;DTXSID70356667;AKOS024328504

Chemical Property of [1]Benzothieno[3,2-b]quinoline

Chemical Property:

• PSA: 41.13000
• LogP: 4.60270
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 235.04557046
• Heavy Atom Count: 17
• Complexity: 293

Purity/Quality:

99% ^*data from raw suppliers

(1)-BENZOTHIENO-(3,2-B)QUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C3C(=N2)C4=CC=CC=C4S3

Technology Process of [1]Benzothieno[3,2-b]quinoline

There total 20 articles about [1]Benzothieno[3,2-b]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-chloro-2-benzothiophene (96907-90-3) + aniline (62-53-3) → benzo[4,5]thieno[3,2-b]quinoline (243-68-5)

Guidance literature:

at 140 - 170 ℃; for 2h;

DOI:10.1007/BF00504217

Reference yield: 85.0%

11-chloro[1]benzothieno[3,2-b]quinoline (35771-74-5) → benzo[4,5]thieno[3,2-b]quinoline (243-68-5)

Guidance literature:

With hydrogen; acetic acid; palladium on activated charcoal; at 20 ℃; for 6h; under 3102.89 - 3361.46 Torr;

DOI:10.1016/j.bmc.2006.10.062

Reference yield: 45.0%

anthranil (271-58-9) + (benzo[b]thiophen-3-yl)zinc pivalate → benzo[4,5]thieno[3,2-b]quinoline (243-68-5)

Guidance literature:

With cobalt(II) chloride; In tetrahydrofuran; at 23 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jacs.8b11466

upstream raw materials:

3-hydroxy-benzo[b]thiophene-2-carboxylic acid

o-aminobenzaldehyde

2-Phenylquinoline

3-chloro-2-benzothiophene

Refernces

• 1、 Chen, Yong-Jia,Liu, Hua,Zhang, Shao-Yong,Li, Hu,Ma, Kun-Yuan,Liu, Ying-Qian,Yin, Xiao-Dan,Zhou, Rui,Yan, Yin-Fang,Wang, Ren-Xuan,He, Ying-Hui,Chu, Qing-Ru,Tang, Chen. "Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi". . p. 1259 - 1271. Retrieved 2021/02/16.
• 2、 Zhu, Xue Y.,Mardenborough, Leroy G.,Li, Shouming,Khan, Abdul,Zhang, Wang,Fan, Pincheng,Jacob, Melissa,Khan, Shabana,Walker, Larry,Ablordeppey, Seth Y.. "Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents". . p. 686 - 695. Retrieved 2007/10/03.