2-(4-methoxyphenyl)-1,2-diphenyl-ethanone

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1,2-diphenyl-ethanone
• CAS No.: 5543-97-5
• Molecular Formula: C21H18 O2
• Molecular Weight: 302.373
• Hs Code.: 2914509090
• Mol file: 5543-97-5.mol

Synonyms:Acetophenone,2-(p-methoxyphenyl)-2-phenyl- (7CI,8CI);2-(4-Methoxyphenyl)-1,2-diphenylethanone; 2-p-Anisyl-1,2-diphenylethanone; NSC41231; a-(4-Methoxyphenyl)deoxybenzoin

Chemical Property of 2-(4-methoxyphenyl)-1,2-diphenyl-ethanone

Chemical Property:

• Vapor Pressure: 1.72E-08mmHg at 25°C
• Boiling Point: 455.7°Cat760mmHg
• Flash Point: 195.8°C
• PSA: 26.30000
• Density: 1.121g/cm³
• LogP: 4.71000
• Solubility.: Chloroform, Ethyl Acetate

Purity/Quality:

99% ^*data from raw suppliers

2-(p-Methoxyphenyl)-2-phenyl-acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of clomiphene and tamoxifen analogs.

Technology Process of 2-(4-methoxyphenyl)-1,2-diphenyl-ethanone

There total 44 articles about 2-(4-methoxyphenyl)-1,2-diphenyl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phenyl benzyl ketone (451-40-1) + 1-bromo-4-methoxy-benzene (104-92-7) → 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one (5543-97-5)

Guidance literature:

With potassium phosphate; tetrabutylammomium bromide; water; palladium diacetate; Diphenylphosphine oxide; In 1,4-dioxane; at 160 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201701596

Reference yield: 94.0%

2-(4-methoxyphenyl)-1,1-diphenylethane-1,2-diol (4237-52-9) → 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one (5543-97-5)

Guidance literature:

With aluminium trichloride; at 20 ℃; for 0.0333333h;

DOI:10.3390/60500442

Reference yield: 89.0%

2-(4-methoxyphenyl)-1,2-diphenylethanol (55681-31-7) → 2-(4-methoxyphenyl)-1,2-diphenylethan-1-one (5543-97-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1002/ejoc.201700467

upstream raw materials:

2-(4-methoxy-phenyl)-1,2-diphenyl-ethanone-dimethylacetal

1-(4-methoxy-phenyl)-1,2-diphenyl-ethane-1,2-diol

2-hydroxy-2-phenylacetophenone

methoxybenzene

Downstream raw materials:

(trans)-1-chloro-2-(4-β-chloroethoxyphenyl)-1,2-diphenylethene

(R,S)-1-(4-benzyloxyphenyl)-1,2-diphenyl-butan-2-ol

2-(4-benzyloxyphenyl)-1,2-diphenyl-ethan-1-one

Refernces

• 1、 Li, Zhirong,Peng, Yonggang,Wu, Tao. "Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes". supporting information. . Retrieved 2021/02/16.
• 2、 Astarloa, Iratxe,SanMartin, Raul,Herrero, María Teresa,Domínguez, Esther. "Aqueous α-Arylation of Mono- and Diarylethanone Enolates at Low Catalyst Loading". supporting information. p. 1711 - 1718. Retrieved 2018/03/21.