Nε-acryloyl-L-lysin

Base Information

• Chemical Name: Nε-acryloyl-L-lysin
• CAS No.: 48065-82-3
• Molecular Formula: C9H16N2O3
• Molecular Weight: 200.2349
• Mol file: 48065-82-3.mol

Synonyms:

Chemical Property of Nε-acryloyl-L-lysin

Chemical Property:

• Vapor Pressure: 1.67E-09mmHg at 25°C
• Boiling Point: 453.9°Cat760mmHg
• PKA: 2.53±0.24(Predicted)
• Flash Point: 228.3°C
• PSA: 92.42000
• Density: 1.132g/cm³
• LogP: 0.96200

Purity/Quality:

99% ^*data from raw suppliers

H-L-Lys(Acryloyl)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Nε-acryloyl-L-lysin

There total 12 articles about Nε-acryloyl-L-lysin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

→ Nε-acryloyl-(S)-lysine (48065-82-3)

Guidance literature:

With 8-quinolinol; In chloroform; water; for 12h;

DOI:10.1080/00397910500212932

Reference yield: 92.0%

L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) + acryloyl chloride (814-68-6,25189-84-8) → Nε-acryloyl-(S)-lysine (48065-82-3)

Guidance literature:

L-Lysine hydrochloride; With copper carbonate hydroxide; In water; at 101 - 105 ℃; for 3h;

acryloyl chloride; With sodium hydrogencarbonate; sodium hydroxide; In water; at 0 - 20 ℃; pH=8.5 - 9;

DOI:10.1016/j.carbpol.2015.09.095

Reference yield: 69.76%

C9H16N2O3*Cu(2+) → Nε-acryloyl-(S)-lysine (48065-82-3)

Guidance literature:

With hydrogen sulfide; pyrographite; In water; at 100 ℃; Cooling with ice;

upstream raw materials:

acrylic acid anhydride

(2S)-2-{[(tert-butoxy)carbonyl]amino}-6-(prop-2-enamido)hexanoic acid

Boc-Lys-OH

L-Lysine hydrochloride

Refernces

• 1、 Nagaoka, Shoji,Shundo, Atsuomi,Satoh, Takao,Nagira, Kazuhiko,Kishi, Ryoich,Ueno, Katsuhiko,Iio, Kokoro,Ihara, Hirotaka. "Method for a convenient and efficient synthesis of amino acid acrylic monomers with zwitterionic structure". . p. 2529 - 2534. Retrieved 2005.
• 2、 -. "BIOCOMPATIBLE POLYMERIC DRUG CARRIERS FOR DELIVERING ACTIVE AGENTS". Page/Page column 43. . Retrieved 2021/05/07.
• 3、 -. "A GENETICALLY ENCODED, PHAGE-DISPLAYED CYCLIC PEPTIDE LIBRARY AND METHODS OF MAKING THE SAME". Paragraph 0094; 00117-00118; 00120-00122. . Retrieved 2020/12/07.