tetrahydropyran-4,4-dicarboxylic acid

Base Information

• Chemical Name: tetrahydropyran-4,4-dicarboxylic acid
• CAS No.: 5337-04-2
• Molecular Formula: C7H10O5
• Molecular Weight: 174.1513
• Hs Code.: 2932999099
• Mol file: 5337-04-2.mol

Synonyms:oxane-4,4-dicarboxylic acid;

Chemical Property of tetrahydropyran-4,4-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 5.91E-08mmHg at 25°C
• Melting Point: 87 °C
• Boiling Point: 412.3°Cat760mmHg
• PKA: 1.75±0.20(Predicted)
• Flash Point: 176°C
• PSA: 83.83000
• Density: 1.446g/cm³
• LogP: -0.04760
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Dihydro-2H-pyran-4,4(3H)-dicarboxylicacid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tetrahydropyran-4,4-dicarboxylic acid

There total 6 articles about tetrahydropyran-4,4-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tetrahydro-pyran-4,4-dicarboxylic acid diethyl ester (5382-77-4) → tetrahydro-4H-pyran-4,4-dicarboxylic acid (5337-04-2)

Guidance literature:

tetrahydro-pyran-4,4-dicarboxylic acid diethyl ester; With sodium hydroxide; In water; at 20 ℃; for 28h;

With hydrogenchloride; In water;

Reference yield:

dihydro-2H-pyran-4,4(3H)-dicarbonitrile (111511-90-1) → tetrahydro-4H-pyran-4,4-dicarboxylic acid (5337-04-2)

Guidance literature:

With sodium hydroxide; In ethanol; water;

Reference yield:

3-oxa-1,5-dichloropentane (111-44-4) + malonic acid dimethyl ester (108-59-8) → tetrahydro-4H-pyran-4,4-dicarboxylic acid (5337-04-2)

Guidance literature:

malonic acid dimethyl ester; With sodium methylate; In N,N-dimethyl-formamide; at 5 ℃;

3-oxa-1,5-dichloropentane; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 20h;

With hydrogenchloride; sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

4-cyano-tetrahydro-pyran-4-carboxylic acid ethyl ester

tetrahydro-pyran-4,4-dicarboxylic acid diethyl ester

2,2'-diiodoethyl ether

diethyl malonate

Downstream raw materials:

tetrahydro-2H-pyran-4-carboxylic acid

tetrahydro-thiopyran-4-carboxylic acid methyl ester

(tetrahydro-2H-thiopyran-4-yl)methanol

(1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-pyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester

Refernces

• 1、 -. "2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS". Page/Page column 110-111. . Retrieved 2008/12/05.
• 2、 -. "INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE". Page/Page column 52. . Retrieved 2010/02/11.