Tetrahydro-2H-pyran-4-carboxylic acid

Base Information

• Chemical Name: Tetrahydro-2H-pyran-4-carboxylic acid
• CAS No.: 5337-03-1
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Hs Code.: 29339900
• Mol file: 5337-03-1.mol

Synonyms:Pyran-4-carboxylicacid, tetrahydro- (6CI,7CI);4-Tetrahydropyranylcarboxylic acid;NSC 403;Tetrahydro-4-pyrancarboxylic acid;

Chemical Property of Tetrahydro-2H-pyran-4-carboxylic acid

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00282mmHg at 25°C
• Melting Point: 87-89 °C
• Refractive Index: 1.4315 (estimate)
• Boiling Point: 264.5 °C at 760 mmHg
• PKA: 4.43±0.20(Predicted)
• Flash Point: 114 °C
• PSA: 46.53000
• Density: 1.185 g/cm³
• LogP: 0.49760
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydro-2H-pyran-4-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22-20/21/22
• Safety Statements: 26-36/37/39-22-39-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-2H-pyran-4-carboxylic acid

There total 19 articles about Tetrahydro-2H-pyran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tetrahydropyran-4-carboxylic acid methyl ester (110238-91-0) → tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1)

Guidance literature:

With water; sodium hydroxide; In ethanol; at 20 ℃;

DOI:10.1021/jm101431v

Reference yield: 95.0%

(tetrahydro-2H-pyran-4-yl)methanol (14774-37-9) → tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1)

Guidance literature:

With 1-hydroxycyclohexyl phenyl ketone; sodium hydroxide; In 1,2-dimethoxyethane; at 80 ℃; chemoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.1c02188

Reference yield: 88.0%

4-cyanotetrahydro-2H-pyran-4-carboxylic acid (848821-06-7) → tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1)

Guidance literature:

With hydrogenchloride; water; at 100 ℃; for 9h; Product distribution / selectivity;

upstream raw materials:

tetrahydro-4H-pyran-4,4-dicarboxylic acid

3-oxa-1,5-dichloropentane

diethyl malonate

tetrahydro-4-(methoxymethylene)-2H-pyran

Downstream raw materials:

ethyl tetrahydro-2H-pyran-4-carboxylate

4-aminotetrahydropyran

(tetrahydro-2H-pyran-4-yl)methanol

tetrahydro-2H-pyran-4-carbonylchloride

Refernces

• 1、 -. "Important intermediate tetrahydropyrane-4-formic acid preparation method". Paragraph 0018-0052. . Retrieved 2019/01/13.
• 2、 -. "Compounds with cardiac myosin activating function and pharmaceutical composition containing the same for treating or preventing heart failure". Paragraph 1324-1328. . Retrieved 2016/10/07.