N-(2,4-Dichlorophenyl)formamide

Base Information

• Chemical Name: N-(2,4-Dichlorophenyl)formamide
• CAS No.: 22923-00-8
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.029
• Hs Code.: 2924299090
• European Community (EC) Number: 245-331-3
• DSSTox Substance ID: DTXSID00177468
• Nikkaji Number: J318.363G
• Wikidata: Q83047796
• Mol file: 22923-00-8.mol

Synonyms:N-(2,4-Dichlorophenyl)formamide;22923-00-8;EINECS 245-331-3;Formamide, N-(2,4-dichlorophenyl)-;2',4'-Dichloroformanilide;SCHEMBL325006;(2,4-Dichlorophenyl)formamide;DTXSID00177468;2',5'-DICHLOROFORMANILIDE;AKOS000297084

Chemical Property of N-(2,4-Dichlorophenyl)formamide

Chemical Property:

• Vapor Pressure: 3.27E-05mmHg at 25°C
• Melting Point: 158-159 °C
• Boiling Point: 354.8°Cat760mmHg
• PKA: 13.19±0.70(Predicted)
• Flash Point: 168.4°C
• PSA: 32.59000
• Density: 1.46g/cm³
• LogP: 3.21120
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 188.9748192
• Heavy Atom Count: 11
• Complexity: 142

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'',4''-Dichloroformanilide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1Cl)Cl)NC=O

Technology Process of N-(2,4-Dichlorophenyl)formamide

There total 14 articles about N-(2,4-Dichlorophenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4-Dichloroaniline (554-00-7,51908-09-9) + formyl acetic anhydride (2258-42-6) → N-(2,4-dichlorophenyl)-formamide (22923-00-8)

Guidance literature:

In tetrahydrofuran; at -20 ℃; for 0.25h;

DOI:10.1016/S0040-4039(00)87603-0

Reference yield: 98.0%

formic acid (64-18-6) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → N-(2,4-dichlorophenyl)-formamide (22923-00-8)

Guidance literature:

With NaY zeolite functionalized by sulfamic acid/Cu(OAc)₂; at 20 ℃;

DOI:10.1016/j.cclet.2017.04.029

Reference yield: 88.51%

sodium formate (141-53-7) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → N-(2,4-dichlorophenyl)-formamide (22923-00-8)

Guidance literature:

With formic acid; for 12h; Reflux;

DOI:10.1016/j.bmc.2016.12.002

upstream raw materials:

formic acid

2,4-Dichloroaniline

Formanilid

formyl acetic anhydride

Downstream raw materials:

N'-(4-chloro-phenyl)-N-(2,4-dichloro-phenyl)-N-formyl-urea

2,4-Dichlor-phenylimino-kohlensaeure-thio-<4-nitro-phenylester>-chlorid

2,4-Dichlor-phenylimino-kohlensaeure-thiopentachlorphenylester-chlorid

2,4-dichlorophenyl isocyanide dichloride

Refernces

• 1、 Kazemi, Samira,Mobinikhaledi, Akbar,Zendehdel, Mojgan. "NaY zeolite functionalized by sulfamic acid/Cu(OAc)2 as a new and reusable heterogeneous hybrid catalyst for efficient solvent-free formylation of amines". . p. 1767 - 1772. Retrieved 2017/07/27.
• 2、 Wang, Xiaoqiang,Jiang, Nan,Zhao, Sijia,Xi, Shuancheng,Wang, Jiao,Jing, Tongfei,Zhang, Wenyu,Guo, Ming,Gong, Ping,Zhai, Xin. "Design, synthesis and biological evaluation of novel 4-(2-fluorophenoxy)quinoline derivatives as selective c-Met inhibitors". . p. 886 - 896. Retrieved 2017/02/05.