2-(6-oxo-3H-purin-9-yl)acetic acid

Base Information

• Chemical Name: 2-(6-oxo-3H-purin-9-yl)acetic acid
• CAS No.: 6298-53-9
• Molecular Formula: C7H6 N4 O3
• Molecular Weight: 194.15
• Hs Code.: 2933990090
• Mol file: 6298-53-9.mol

Synonyms:9H-Purine-9-aceticacid, 6-hydroxy- (6CI,8CI,9CI); 9-Carboxymethylhypoxanthine; NSC 41848

Chemical Property of 2-(6-oxo-3H-purin-9-yl)acetic acid

Chemical Property:

• Vapor Pressure: 5.22E-16mmHg at 25°C
• Boiling Point: 615.5°C at 760 mmHg
• Flash Point: 326.1°C
• PSA: 100.87000
• Density: 1.84g/cm³
• LogP: -0.79580

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(6-Oxo-1H-purin-9(6H)-yl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(6-oxo-3H-purin-9-yl)acetic acid

There total 12 articles about 2-(6-oxo-3H-purin-9-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(6-amino-9H-purin-9-yl)acetic acid (20128-29-4) → 9-carboxymethylhypoxanthine (6298-53-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; at 20 ℃;

DOI:10.1016/j.bmc.2005.11.013

Reference yield: 56.0%

Ethyl ester of hypoxanthinyl-9-acetic acid (55175-33-2) → 2-(6-hydroxy-9H-purin-9-yl)acetic acid (6298-53-9)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2019.03.049

Reference yield: 56.0%

[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-yl]-acetic acid ethyl ester (409304-23-0) → 9-carboxymethylhypoxanthine (6298-53-9)

Guidance literature:

With hydrogenchloride; for 2h; Heating;

DOI:10.1023/A:1011612823352

upstream raw materials:

6-benzyloxypurine

Ethyl ester of hypoxanthinyl-9-acetic acid

6-chloropurine

[6-(3-methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-purin-9-yl]-acetic acid ethyl ester

Refernces

• 1、 -. "Modified Nucleobases with Uniform H-Bonding Interactions, Homo- and Hetero-Basepair Bias, and Mismatch Discrimination". Paragraph 0013. . Retrieved 2021/07/30.
• 2、 Huang, Liusheng,Kerns, Robert J.. "Diversity-oriented chemical modification of heparin: Identification of charge-reduced N-acyl heparin derivatives having increased selectivity for heparin-binding proteins". . p. 2300 - 2313. Retrieved 2007/10/03.