55175-33-2

Basic information

• Product Name: Ethyl (6-hydroxy-9H-purin-9-yl)acetate
• Synonyms: (6-Hydroxy-9H-purine-9-yl)acetic acid ethyl ester;2-[(6-Oxo-1,9-dihydro-6H-purin)-9-yl]acetic acid ethyl ester;6-Hydroxy-9H-purine-9-acetic acid ethyl ester;Ethyl (6-hydroxy-9H-purin-9-yl)acetate
• CAS NO: 55175-33-2
• Molecular Formula: C9H10N4O3
• Molecular Weight: 222.2
• Mol File: 55175-33-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethyl (6-hydroxy-9H-purin-9-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl (6-hydroxy-9H-purin-9-yl)acetate(55175-33-2)
• EPA Substance Registry System: Ethyl (6-hydroxy-9H-purin-9-yl)acetate(55175-33-2)

Safety Data

• Hazardous Substances Data: 55175-33-2(Hazardous Substances Data)

Upstream product

• 112630-42-9 Ethyl 2-(5-Amino-4-aminocarbonylimidazol-1-yl)acetate 
• 122-51-0 orthoformic acid triethyl ester 
• 87-42-3 6-chloropurine 
• 57500-07-9 6-benzyloxypurine 
• 25477-96-7 ethyl 2-(9H-adenin-9-yl)acetate 

Downstream Products

• 6298-53-9 2-(6-hydroxy-9H-purin-9-yl)acetic acid 

Relevant articles and documents

Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands

Introducing purine bases to P2-ligands might enhance the potency of Human Immunodeficiency Virus-1 (HIV-1) protease inhibitory because of the carbonyl and NH groups promoting the formation of extensive H-bonding interactions. In this work, thirty-three compounds are synthesized and evaluated, among which inhibitors 16a, 16f and 16j containing N-2-(6-substituted-9H-purin-9-yl)acetamide as the P2-ligands along with 4-methoxylphenylsulfonamide as the P2′-ligand, display potent inhibitory effect on the activity of HIV-1 protease with IC50 43 nM, 42 nM and 68 nM in vitro, respectively.

SYNTHESIS OF MODIFIED AMINO ACIDS CONTAINING NUCLEIC ACID PURINE BASES

The reaction of hydrazides of adenylyl- or hypoxanthinyl-9-alkylcarboxylic acids with sodium nitrite in acid media gives reactive azides of purinyl-9-alkylcarboxylic acids which condense with α(ω)-aminocarboxylic and α,ω-diaminocarboxylic acids to give Nα(Nω)-(adenylyl-9-alkanoyl)aminocarboxylic, Nα-(adenylyl-9-)- and Nω-(hypoxanthinyl-9-alkanoyl)-α,ω-diaminocarboxylic acids.The deamination of Nω-(adenylyl-9-alkanoyl)aminocarboxylic acids gives Nω-(hypoxanthinyl-9-alkanoyl)aminocarboxylic acids.