25477-96-7Relevant articles and documents
Thermal-induced dynamic self-assembly of adenine-grafted polyoxometalate complexes
He, Zhenfeng,Yan, Yi,Li, Bao,Ai, Hui,Wang, Huanbing,Li, Haolong,Wu, Lixin
, p. 10043 - 10051 (2012)
A new kind of organic-inorganic hybrid complexes based on polyoxometalate were synthesized through symmetrically grafting two adeninyl groups onto Anderson-type MnMo6 clusters and encapsulating the clusters by organic surfactants. The resultant complexes exhibited thermal-induced dynamic self-assembly behaviors which greatly depended on the ambient temperature and the chain length of cationic surfactants. With the encapsulation of a short surfactant tetrabutyl ammonium, the complex assembled into fibrous, rod-like, and tubular architectures respectively upon heating; while for the case of using a long surfactant dimethyldioctadecyl ammonium as counter ions, the assemblies of the complex transformed from fibers to spheres with the increased temperature. Moreover, the two types of transformations were both reversible during a cooling process. The related mechanism was investigated by combining multiple characterization methods including X-ray crystallography, XPS, FT-IR and temperature-dependent 1H NMR, which indicated that such a thermal-induced morphological transformation resulted from a synergy effect of the variation of the multiple hydrogen bonds among the complexes and the rearrangement of the surfactants surrounding the MnMo6 clusters. These results demonstrated a new concept that hydrogen bonds can be rationally employed as the driving force for the fabrication of polyoxometalate-based materials with smart responsive properties.
Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands
Zhu, Mei,Dong, Biao,Zhang, Guo-Ning,Wang, Ju-Xian,Cen, Shan,Wang, Yu-Cheng
supporting information, p. 1541 - 1545 (2019/04/25)
Introducing purine bases to P2-ligands might enhance the potency of Human Immunodeficiency Virus-1 (HIV-1) protease inhibitory because of the carbonyl and NH groups promoting the formation of extensive H-bonding interactions. In this work, thirty-three compounds are synthesized and evaluated, among which inhibitors 16a, 16f and 16j containing N-2-(6-substituted-9H-purin-9-yl)acetamide as the P2-ligands along with 4-methoxylphenylsulfonamide as the P2′-ligand, display potent inhibitory effect on the activity of HIV-1 protease with IC50 43 nM, 42 nM and 68 nM in vitro, respectively.
Simple and efficient synthesis of novel glycosyl thiourea derivatives as potential antitumor agents
Shusheng, Zhang,Tianrong, Zhan,Kun, Cheng,Youfeng, Xia,Bo, Yang
experimental part, p. 2778 - 2783 (2009/04/11)
The practical synthesis of pseudonucleosides incorporating thiourea derivative by coupling of monosaccharides (d-galactose, d-glucose and d-xylose) per-O-acetylated glycosyl isothiocyanates and different heterocyclic hydrazide derivatives is reported. The method involves the preparation of per-O-acetylated glycosyl isothiocyanates from per-O-acetylated sugars (two-step synthesis), which couple with heterocyclic hydrazides from amines to give thiourea-linked pseudonucleosides. All newly synthesized pseudonucleosides were assayed against human lung cancer-cell lines (PG) and human liver cancer-cell lines (BEL-7402) in vitro. The 2-(4-methoxybenzamide)-benzoimidazole-1-yl-acetyl pseudonucleosides showed moderate inhibition against these two cancer-cell lines with EC50 from 22.8 to 76.4 μM and from 54.9 to 82.4 μM, respectively. And the other compounds did not demonstrate any significant cytotoxicity even at concentrations up to 200 μM.
