6298-53-9 Usage
Description
2-(6-oxo-3H-purin-9-yl)acetic acid, also known as the oxidized form of guanosine, is a chemical compound that consists of a purine base (guanine) attached to an acetic acid molecule. It is an important intermediate in the metabolic pathway of guanine, which is a key component of DNA and RNA. 2-(6-oxo-3H-purin-9-yl)acetic acid plays a crucial role in the regulation of cellular processes and is involved in the synthesis and breakdown of nucleic acids.
Uses
Used in Pharmaceutical Development:
2-(6-oxo-3H-purin-9-yl)acetic acid is used as a key intermediate in the development of pharmaceutical drugs targeting guanine metabolism for the treatment of certain genetic and metabolic disorders.
Used in Research Applications:
In the scientific community, 2-(6-oxo-3H-purin-9-yl)acetic acid is utilized as a research tool to study the regulation of cellular processes and the synthesis and breakdown of nucleic acids, contributing to a better understanding of guanine's role in DNA and RNA metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 6298-53-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,9 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 6298-53:
(6*6)+(5*2)+(4*9)+(3*8)+(2*5)+(1*3)=119
119 % 10 = 9
So 6298-53-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N4O3/c12-4(13)1-11-3-10-5-6(11)8-2-9-7(5)14/h2-3H,1H2,(H,12,13)(H,8,9,14)
6298-53-9Relevant articles and documents
Synthesis of 9-substituted derivatives of 6-(nitro-imidazolyl)thiopurines
Aleksandrova,Kochergin,Persanova,Korsunskii,Shlikhunova
, p. 610 - 614 (2001)
The synthesis has been achieved of a series of 9-substituted derivatives of 6-(4-nitroimidazol-5-yl)- and 6-(5-nitroimidazol-4-yl)thiopurines by the reaction of 6-(nitroimidazolyl)thiopurines with alkyl and aralkyl halides, haloalcohols, haloacids and the
Synthesis and biological evaluation of new HIV-1 protease inhibitors with purine bases as P2-ligands
Zhu, Mei,Dong, Biao,Zhang, Guo-Ning,Wang, Ju-Xian,Cen, Shan,Wang, Yu-Cheng
, p. 1541 - 1545 (2019/04/25)
Introducing purine bases to P2-ligands might enhance the potency of Human Immunodeficiency Virus-1 (HIV-1) protease inhibitory because of the carbonyl and NH groups promoting the formation of extensive H-bonding interactions. In this work, thirty-three compounds are synthesized and evaluated, among which inhibitors 16a, 16f and 16j containing N-2-(6-substituted-9H-purin-9-yl)acetamide as the P2-ligands along with 4-methoxylphenylsulfonamide as the P2′-ligand, display potent inhibitory effect on the activity of HIV-1 protease with IC50 43 nM, 42 nM and 68 nM in vitro, respectively.
