4-chloro-N-hydroxybenzenesulfonamide

Base Information

• Chemical Name: 4-chloro-N-hydroxybenzenesulfonamide
• CAS No.: 50695-53-9
• Molecular Formula: C6H6ClNO3S
• Molecular Weight: 207.638
• Mol file: 50695-53-9.mol

Synonyms:

Chemical Property of 4-chloro-N-hydroxybenzenesulfonamide

Chemical Property:

• Vapor Pressure: 2.47E-06mmHg at 25°C
• Boiling Point: 376.4°Cat760mmHg
• Flash Point: 181.4°C
• Density: 1.561g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-N-hydroxybenzenesulfonamide

There total 2 articles about 4-chloro-N-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-chlorobenzenesulfonyl chloride (98-60-2) → N-(p-chlorobenzenesulfonyl)hydroxylamine (50695-53-9)

Guidance literature:

With hydroxylamine hydrochloride; magnesium oxide; In tetrahydrofuran; methanol; water; at 25 ℃;

DOI:10.1039/c7ob01390f

Reference yield:

→ N-(p-chlorobenzenesulfonyl)hydroxylamine (50695-53-9)

Guidance literature:

4-Chlorbenzolsulfochlorid, NH2OH;

DOI:10.1248/cpb.21.2566

Reference yield: 98.0%

indole (120-72-9) + N-(p-chlorobenzenesulfonyl)hydroxylamine (50695-53-9) → 3-((4-chlorophenyl)thio)-1H-indole (32884-73-4)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; iodine; In butan-1-ol; at 120 ℃; for 15h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c7ob01390f

upstream raw materials:

4-chlorobenzenesulfonyl chloride

Downstream raw materials:

N-(p-chlorobenzenesulfonyl)-N,O-bis(trimethylsilyl)hydroxylamine

N-acetyl-N-(acetyloxy)-4-chlorobenzenesulfonamide

N-benzoyl-N-(benzoyloxy)-4-chlorobenzenesulfonamide

Z-Gly-OV

Refernces

• 1、 Nagasawa, Herbert T.,DeMaster, Eugene G.,Goon, David J. W.,Kawle, Sagar P.,Shirota, Frances N.. "Carbethoxylating Agents as Inhibitors of Aldehyde Dehydrogenase". . p. 1872 - 1876. Retrieved 1995.