2-(Furan-2-yl)benzo[d]oxazole

Base Information

• Chemical Name: 2-(Furan-2-yl)benzo[d]oxazole
• CAS No.: 881-60-7
• Molecular Formula: C11H7NO2
• Molecular Weight: 185.182
• DSSTox Substance ID: DTXSID30359093
• Nikkaji Number: J315.662A
• Wikidata: Q82140111
• ChEMBL ID: CHEMBL3099679
• Mol file: 881-60-7.mol

Synonyms:2-(Furan-2-yl)benzo[d]oxazole;881-60-7;CHEMBL3099679;2-(furan-2-yl)-1,3-benzoxazole;2-(2-Furyl)benzoxazole;SCHEMBL2223897;DTXSID30359093;BDBM50444532;AKOS003264756

Chemical Property of 2-(Furan-2-yl)benzo[d]oxazole

Chemical Property:

• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 185.047678466
• Heavy Atom Count: 14
• Complexity: 210

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=C(O2)C3=CC=CO3

Technology Process of 2-(Furan-2-yl)benzo[d]oxazole

There total 2 articles about 2-(Furan-2-yl)benzo[d]oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(furan-2-yl)methylene]-2-methoxybenzenamine (14744-30-0) → 2-furancarbonitrile (617-90-3) + salicylonitrile (611-20-1) + 2-(furan-2-yl)benzoxazole (881-60-7)

Guidance literature:

at 700 ℃; for 1h; under 0.01 Torr; flash vacuum pyrolysis;

DOI:10.1002/jccs.201190029

Reference yield:

2-furfurylideneamino-phenol (6078-02-0) → 2-(furan-2-yl)benzoxazole (881-60-7) + 2-Furan-2-yl-2,3-dihydro-benzooxazole + cis-N-(2-Furanylmethylene)-o-aminophenol (6078-02-0)

Guidance literature:

In methyl cyclohexane; Title compound not separated from byproducts; Ambient temperature; Irradiation;

DOI:10.1021/jo00334a029

Reference yield: 80.0%

2-(furan-2-yl)benzoxazole (881-60-7) + methyl 3-((tert-butyldimethylsilyl)oxy)-2-diazopent-3-enoate (1246011-22-2) → C23H29NO5Si

Guidance literature:

With silver hexafluoroantimonate; In chloroform; at 20 ℃; for 12h; regioselective reaction; Molecular sieve;

DOI:10.1002/anie.202101641

upstream raw materials:

2-furfurylideneamino-phenol

N-[(furan-2-yl)methylene]-2-methoxybenzenamine

Downstream raw materials:

[5-(1,3-benzoxazol-2-yl)furan-2-yl]phenylmethanone

Refernces

• 1、 Tauer, Erich,Grellmann, Karl H.. "Photochemical and Thermal Reactions of Aromatic Schiff Bases". . p. 4252 - 4258. Retrieved 2007/10/02.