Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-

Base Information

• Chemical Name: Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-
• CAS No.: 883195-08-2
• Molecular Formula: C11H23N3
• Molecular Weight: 197.324
• Mol file: 883195-08-2.mol

Synonyms:

Chemical Property of Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans-

There total 9 articles about Cyclohexanamine, 4-(4-methyl-1-piperazinyl)-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(trans)-N,N-dibenzyl-4-(4-methylpiperazin-1-yl)cyclohexanamine (1119283-62-3) → (trans)-4-(4-methylpiperazin-1-yl)cyclohexanamine (883195-08-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 - 30 ℃; for 12h; under 2280.15 Torr;

Reference yield:

C13H25N3O → (trans)-4-(4-methylpiperazin-1-yl)cyclohexanamine (883195-08-2)

Guidance literature:

With hydrogenchloride; In water; at 95 - 106 ℃; for 18.5h; Large scale;

Reference yield:

1-methyl-piperazine (109-01-3) → (trans)-4-(4-methylpiperazin-1-yl)cyclohexanamine (883195-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 12 h

2.1: hydrogen / palladium 10% on activated carbon / methanol / 12 h / 2280.15 Torr

2.3: pH 11

With hydrogen; sodium tris(acetoxy)borohydride; acetic acid; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

trans-4-(dibenzylamino)cyclohexanol

trans-4-aminocyclohexanol hydrochloride

4-(dibenzylamino)cyclohexanone

(trans)-N,N-dibenzyl-4-(4-methylpiperazin-1-yl)cyclohexanamine

Downstream raw materials:

7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(trans)-4-(4-methylpiperazin-1-yl)cyclohexyl]-2,3-dihydrobenzofuran-4-carboxamide

7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,2-dimethyl-N-[(trans)-4-(4-methylpiperazin-1-yl)cyclohexyl]-3H-benzofuran-4-carboxamide

Refernces

• 1、 -. "CRYSTALLINE FORMS OF PYRIMIDINO DIAZEPINE DERIVATIVE". . . Retrieved 2021/02/26.
• 2、 -. "DIHYDROPTERIDINONE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF". . . Retrieved 2012/07/28.