4-(dibenzylamino)cyclohexanone

Base Information

• Chemical Name: 4-(dibenzylamino)cyclohexanone
• CAS No.: 149506-79-6
• Molecular Formula: C20H23NO
• Molecular Weight: 293.409
• Hs Code.: 2922399090
• Mol file: 149506-79-6.mol

Synonyms:4-(dibenzylamino)cyclohexan-1-one;

Chemical Property of 4-(dibenzylamino)cyclohexanone

Chemical Property:

• Boiling Point: 427.1±40.0 °C(Predicted)
• PKA: 7.20±0.20(Predicted)
• PSA: 20.31000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 4.20050
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-(Dibenzylamino)cyclohexanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(dibenzylamino)cyclohexanone

There total 20 articles about 4-(dibenzylamino)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-4-(dibenzylamino)cyclohexanol (149506-81-0) → 4-(dibenzylamino)cyclohexanone (149506-79-6)

Guidance literature:

trans-4-(dibenzylamino)cyclohexanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.916667h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

Reference yield: 95.0%

N,N-dibenzyl-1,4-dioxaspiro[4.5]decan-8-amine (168893-04-7) → 4-(dibenzylamino)cyclohexanone (149506-79-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; for 4h; Inert atmosphere; Reflux;

Reference yield: 83.0%

(1r,4r)-4-(dibenzylamino)cyclohexan-1-ol → 4-(dibenzylamino)cyclohexanone (149506-79-6)

Guidance literature:

(1r,4r)-4-(dibenzylamino)cyclohexan-1-ol; With phosphorus pentoxide; dimethyl sulfoxide; In dichloromethane; at 0 ℃; for 1h;

With triethylamine; In dichloromethane; at 0 ℃; for 2h;

With sodium hypochlorite; In dichloromethane; water; at 20 ℃; for 0.666667h;

upstream raw materials:

2-(chloromethyl)iodobenzene

4-(N-benzylamino)cyclohexanone ethylene acetal

N,N-dibenzyl-1,4-dioxaspiro[4.5]decan-8-amine

Chloro-oxo-acetic acid

Downstream raw materials:

4-(morpholin-4-yl)cyclohexan-1-amine

trans-dibenzyl-(4-morpholin-4-yl-cyclohexyl)-amine

(trans)-N,N-dibenzyl-4-(4-methylpiperazin-1-yl)cyclohexanamine

C₂₅H₃₅N₃

Refernces

• 1、 -. "CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS". . . Retrieved 2021/11/26.
• 2、 -. "TREATMENT OF CDK4/6 INHIBITOR RESISTANT NEOPLASTIC DISORDERS". . . Retrieved 2020/10/19.